Overview
A non‑clinical position for a Clinical Trial Statistician to serve as academic lead and provide senior oversight and leadership to the Sheffield Clinical Trials Research Unit (CTRU) oncology clinical trials portfolio. The post holder will lead trial design, grant development, submission, and senior‑level study implementation with a specific focus on oncology‑based CTIMPs (Clinical Trials of Investigational Medicinal Products).
Main duties and responsibilities
* Provide senior oversight and leadership to the CTRU oncology clinical trials portfolio, especially the Yorkshire Cancer Research (YCR) Infrastructure grant, ensuring the project meets its key milestones and deliverables.
* Provide statistical input across the design, conduct, implementation, analysis and reporting of oncology trials within the CTRU portfolio.
* Drive methodological research to advance efficient and patient‑centred trial designs.
* Work collaboratively within a multidisciplinary team including clinicians, statisticians, trial managers and other research professionals.
* Develop a specialist portfolio of oncology research and act as CTRU Lead in collaboration with clinical investigators, designing studies, submitting research applications and securing significant external research income/grant funding.
* Ensure all cancer research studies undertaken under your leadership adhere to randomised controlled trial scientific principles and protocols.
* Oversee quality assurance processes within the CTRU.
* Ensure compliance with all relevant regulatory standards for clinical trials.
* Support preparation for and response to MHRA inspections.
* Lead on the preparation and publication of papers for high‑impact oncology and academic journals.
* Lead on the presentation of findings at international cancer conferences and academic forums.
* Use methodological expertise to undertake research and translational activities that result in demonstrable impact.
* Undertake undergraduate and post‑graduate teaching, supervision and examining within the School of Medicine and Population Health.
* Contribute fully as a researcher, teacher and leader, fulfilling the appropriate requirements of the University's Academic Career Pathway Framework (ACP).
* Make ethical decisions in your role, embedding the University sustainability strategy into your working activities wherever possible.
* Any other duties commensurate with the grade of the post.
Person Specification
* Academic qualifications: Postgraduate qualification in Medical Statistics or a closely related discipline.
* Extensive experience in design and analysis of clinical trials within oncology, with a deep understanding of cancer‑specific trial complexities.
* Expertise in complex and innovative trial designs commonly used in oncology (e.g., adaptive designs, master protocols, umbrella/basket trials, dose‑finding Phase I/II designs, and biomarker‑driven trials).
* High and distinctive standing within and outside academia, including major contributions to the field through academic or professional achievement and recognised expertise.
* Sound understanding of the scientific principles of RCTs, including experience with innovative/adaptive trial designs relevant to precision medicine.
* Proven, substantial experience acting as lead statistician on multi‑centre oncology clinical trials.
* Experience working on CTIMPs and thorough knowledge of the Medicines for Human Use (Clinical Trials) Regulations 2004 and ICH Good Clinical Practice (GCP).
* Extensive experience collaborating with senior clinical investigators to design, develop and secure major research grants (e.g., NIHR, CRUK, MRC or major charities).
* A strong track record of high‑quality, peer‑reviewed clinical trial research papers published in high‑impact journals.
* Leadership and mentorship experience supervising junior staff and mentoring early‑career researchers or clinical fellows.
* Excellent skills in maintaining relationships with Chief Investigators, trial funders and Cancer Patient and Public Involvement (PPI) panels.
* Ability to develop creative approaches to complex trial problems (e.g., recruitment barriers in oncology) with an appreciation for long‑term sustainability and strategic aims.
Further Information
* Grade: Professor up to Band 1.4
* Salary: £71,466 to £75,915 (annual)
* Work arrangement: Full‑time / Part‑time (minimum 0.6 FTE)
* Duration: Permanent
* Line manager: CTRU Director
* Direct reports: Trial Manager, Study Managers, Study Delivery Staff
Disability confident employer – if you have a disability and meet the essential criteria you will be invited to the next stage of the selection process.
Closing Date: 02/06/2026
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