Job Title: Senior Scientist– Translational Genomics,Translational Medicine
Location: Cambridge, UK
Introduction to the role: We are seeking a Senior Scientist to join our Translational Genomicsteam(Cambridge, U.K.) on a fixed termbasis (14 months). The successful candidate would be joininga world classcentrefordiscoveryand development of innovative cancer medicines. Based at the heart of the Cambridge UK biomedical research community you will play a keyrole in thedelivery of datautilizingcutting edgegenomics techniques.You will deliver high qualitybiomarkerdata from human clinical samples andhave the opportunity toimpactanexciting andindustry-leading portfolio of programs frominceptionthrough tolife cycle management.
About the role: The TranslationalMedicineGenomics Lab focuses on the exploratoryanalysis of clinical samples using the best available solutions to maximize value for oncology projects. Our work includes the analysis of fixed and frozen tissues, liquid biopsymaterial, and single cell and spatial genomics. We provide support via a mix of in-house lab analyses, external providers, and collaborators. We generate data to help understand key cancer pathway alterations, guide drug combinations, provide disease linkage data to guideindicationselection and targeted patient populations andunderstandthe dynamics of responseandresistance to therapies.
This role will have a strong focus on hands-on laboratory work. You will be responsible for the planning, design, and execution of high-quality experimental work and documenting, interpreting, and communicating results to appropriate stakeholders and partners. You will be able to work independently but also as a key member of our global team of genomics and data science experts.
Major Responsibilities and Accountabilities:
* Work with UK and Global genomics colleagues, Project Managers and TranslationalMedicine Leads (TMLs) to understand the genomic biomarker needs of clinical studies
* Plan, prioritise, and execute work to deliver to biomarker plans exploiting the most appropriate technologies/assays to deliver high quality data on time and to budget
* Work with Translational, Clinical, Biosamples colleagues, and CRO partners, to access the right samples at the right time
* Lead from the bench to generate data in a modern genomics lab utilising Automation, DNA/RNA extraction, library preparation, NGS, single cell, and other platforms
* Utilise a sample management system and other software and communication tools to track samples, monitor progress, and record data
* Work with team members and aligned production informatics and bioinformatics experts to support data analysis/QC, interpretation and communication back to TML, project team and other stakeholders
* Contribute to maintenance and development of our internal genomics capabilities and development & implementation of new genomic/epigenomic assays or related technologies
* Support colleagues to train in existing and new SOPs
* As required - conceptualize, develop, and execute evaluations of methods, platforms, and emerging technologies which may address areas of unmet need for programmes
* Provide technical advice and genomic biomarker consultation to internal and external partners
* Record and communicate your data accurately, clearly and concisely
* Maintain appropriate documentation, be compliant with all internal and external policies and legal requirements around use of clinical samples, consent, and privacy
Essential skills and experience:
* Advanced degree in a relevant discipline (preferably PhD or equivalent) and at least 4 years post-doctoral experience (or equivalent) utilising advanced molecular biology techniques (academic or industrial setting); Recent/current experience greatly preferred
* Experience of cancer genomics and analysis of oncology clinical specimens
* Strong current laboratory and analytical skills
* Evidence of effective problem-solving, method development, and optimisation
* Ability to understand and work to detailed SOPs and to author and troubleshoot new SOPs
* Excellent oral and written communication skills, able to document work clearly, concisely, and understand and describe its importance to others
* Good organisational and planning skills, ability to manage a portfolio of work, prioritize, and deliver to agreed time and quality
* Good interpersonal skills – able to work effectively with colleagues/collaborators from diverse backgrounds, levels of seniority, and territories
* Meticulous attention to detail, ability to document results to a high standard
Desirable skills and experience:
Although training will be given where required, experience in the following areas would be a distinct advantage:
* Peer-reviewed publications in the cancer biology/cancergenomics field
* Working in a commercial/industrial environment
* Working with DNA/RNA from human clinical materials such asin fixed paraffin-embedded tissues, frozen tissues, plasma (circulating cell-free DNA/cfDNA).
* Hands-on laboratory experience preparing DNA/RNA libraries, targeted NGS, and running NGS platforms
* Work in single cell genomics and/or spatial genomics (e.g. 10x, Parse, GeoMxDSP)
* Tissue culture, handling and purification of cells from clinical samples, e.g. PBMCs
* Tissue dissociation for downstream single cell work
* Developing and running assays (e.g., mutation/copy number) using digital PCR
* Conducting work to Good Clinical Practice (GCP) within a regulatory/quality framework (e.g. ISO15189-, CAP-, CLIA-accredited lab environment).
* Assay development for NGS platforms
* Working with laboratory automation (particularly Biomek liquid handling systems), method development/optimisation
* Analysis and interpretation of NGS data from clinical specimens
* Experience in the biotech/pharmaceutical industry and of the drug development process
When we put unexpected teams in the same room, we unleash ambitious thinking with the power to encourage life‑changing medicines. In‑person working helps us connect, work at pace and challenge perceptions. We work, on average, a minimum of three days per week from the office, while balancing individual flexibility.
Why AstraZeneca?
We are committed to making a difference and have built our business around our passion for science. We’re fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our curiosity and courage drive us to do things that haven’t been done before—empowered to step up, make bold decisions, and learn from successes and failures.
Ready to make a significant impact?
Apply now and join us on this exciting journey!
#J-18808-Ljbffr