Job Description
Main Purpose of the Job
This role will focus on the long-term development of novel experimental methods for the study of the human microbiome. The position will be associated with Prof Quince’s High-resolution Microbiomics group, jointly at Quadram / Earlham. The research programme will be developed by the applicant in conjunction with Prof Quince, but the aim will be to drive forward the next generation of methods in microbiome research. These will include improved strategies for characterising microbial communities in situ to the strain level, for instance, long‑read or single cell sequencing, or novel Hi‑C library preparations. In addition to methods that determine the function of community members, for example utilising metabolomics and metaproteomics.
These methods will be applied to current key questions in microbiome research. Using samples generated from both mouse experiments and human clinical trials we will determine how the microbiome responds to perturbations such as antibiotics, invasions and changes in dietary fibre. We will also explore the consequences to the host of these microbiome responses.
Key Relationships
Internal: Line manager, group members and, as necessary, other researchers, research support staff and students across the Institute.
External: Collaborators.
Main Activities & Responsibilities
– (Specific responsibilities are not listed in the original description.)
Person Profile
Education & Qualifications
* PhD in relevant area of molecular biology
* First degree in relevant scientific area
Specialist Knowledge & Skills
* Ability to independently organise and pursue research agenda
* DNA extraction
* Track‑record of presentations to scientific conferences
* Track‑record of publications in international journals
* High‑level proficiency with molecular biology
* Long‑read sequencing (Nanopore)
Relevant Experience
* Experience with ‘omics data generation
* Direct experience working with microbiome samples
* Experience culturing microbes
* Experience with novel library preparation techniques such as Hi‑C
* Experience of supporting students and junior researchers
Interpersonal & Communication Skills
* Excellent interpersonal skills, with the ability to work well as part of a team
* Excellent communication skills, both written and verbal
* Promotes and strives for continuous improvement
* Demonstrated ability to work independently, using initiative and applying problem solving skills
Additional Requirements
* Attention to detail
* Promotes equality and values diversity
* Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
* Ability to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
* Willingness to work outside standard hours as required
* Ability to maintain confidentiality and security of information where appropriate
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