Overview:
Alnylam seeks a strategic technology leader to drive the strategy, delivery, and governance of platforms supporting Clinical Delivery, Portfolio Management, and Data Science, Statistics, & Epidemiology (DSSE). This role translates business strategy into validated, compliant, and AI-enabled capabilities that accelerate study execution, optimize portfolio analytics, and enable advanced data science and statistical insights. The Senior Director partners closely with Clinical Operations (CPS, GTO), Study Management, Portfolio/PPM leadership, and DSSE to deliver measurable business impact.
Key Responsibilities:
Strategic Partnership & Engagement
* Serve as a thought partner to Clinical Ops (Clinical Portfolio Services, Global Trial Optimization), Study Management, Portfolio/PPM leadership, and DSSE.
* Build and maintain collaborative relationships to anticipate needs, align technology roadmaps, and drive shared outcomes.
Clinical Delivery & Portfolio Technology Leadership
* Own product and platform roadmaps for clinical trial execution, study management, and portfolio analytics (e.g., Medidata Rave EDC, CTMS, Veeva Vault eTMF, CluePoints RBQM).
* Define capability priorities and success metrics (cycle time, inspection outcomes, data quality).
* Govern scope, risk, dependencies, and budgets across clinical and DSSE platforms; drive value realization and cost optimization.
DSSE Enablement
* Partner with DSSE to enable analytics, statistical computing, and real-world evidence generation.
* Integrate data standards (e.g., CDISC SDTM/ADaM, E2B(R3)) and support data stewardship, automation, and AI-enabled insights for clinical and DSSE use cases.
* Champion centralized dashboards and data visualization for clinical and DSSE stakeholders.
Portfolio Analytics & Decision Support
* Support Portfolio/PPM leadership with data-driven insights, scenario modeling, and resource forecasting.
* Enable robust portfolio prioritization and reporting.
Standardization & Governance
* Standardize ways of working in alignment with Alnylam's IT Operating Model.
* Champion test automation, resilient operations, information security, and technology governance for clinical and DSSE platforms.
Qualifications:
Required:
* Advanced degree in Information Technology, Data Science, Computer Science, or related field, with specialized knowledge in clinical development and analytics.
* 12-15+ years in life-sciences technology with 5-8+ years leading delivery for Clinical platforms in GxP environments.
* Deep expertise in 21 CFR Part 11, EU Annex 11, ICH E6(R2); demonstrated inspection-readiness leadership and strong CSV/CSA practices.
* Demonstrated vendor/SOW management with major platform providers (e.g., Veeva, Medidata).
* Strong program/portfolio leadership across complex multi-workstream initiatives; fluency in Agile and product operating models.
* Excellent executive communication and stakeholder engagement; strong analytical and problem-solving skills with a track record of operational excellence and innovation.
Preferred:
* Experience with RBQM/centralized monitoring (e.g., CluePoints).
* Knowledge of CDISC standards, E2B(R3), portfolio analytics, and data visualization.
* Working knowledge of integration patterns (e.g., Boomi), cloud (AWS), automated testing, and data governance in regulated environments.
U.S. Pay Range
$226,800.00 - $306,800.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.