Enara Bio is shining a light on Dark Antigen and T-cell biology to develop cancer immunotherapies designed to improve treatment outcomes for broad populations of cancer patients with solid tumors. Our pioneering EDAPT platform enables us to discover cancer-specific antigens, including HLA-presented and cell surface antigens, from previously uncharted genomic 'dark matter'. The result is a growing library of Dark Antigens that can address the need for novel, cancer-specific targets in solid tumors. Through our proprietary EnTiCE platform, Enara is developing novel bispecific T cell engagers against Dark Antigen targets that are highly prevalent and homogenously expressed across solid tumors.
Based in Oxford, UK, Enara Bio is backed by a strong syndicate of life science investors including RA Capital, Pfizer Ventures, M Ventures, Samsara BioCapital, SV Health Investors, and the Francis Crick Institute.
Role Overview
Enara Bio has established a best-in-class pipeline for the identification of novel, previously undiscovered antigens for development of immunotherapies, using mass spectrometry (MS)-based proteomics and immunopeptidomics. We have recently broadened the application of MS to include the characterisation of biologics and are looking to increase internal capabilities in this area.
We are looking for a highly motivated scientist to join our team who has a passion for MS-based proteomics applied to the exciting field of immuno-oncology. The successful candidate will help in the generation of proteomics data to support the characterization of Enara Bio's novel biotherapeutics as well as supporting our ongoing antigen-discovery pipeline. This role will make a major contribution in supporting our goal of delivering impactful therapies that make a meaningful difference to patients suffering from cancer.
The successful candidate will work closely with key internal and external stakeholders including academic and non-academic partners in immunobiology, biochemistry, protein characterisation and LC/MS-based disciplines. Enara Bio actively promotes a multidisciplinary collaborative approach to working, therefore effective communication is essential to this role as you will be expected to effectively communicate with our collaborators about our scientific research objectives.
Key responsibilities:
* Provide technical leadership on various proteomics analytical workflows with experience in different LCMS based proteomic methods (DDA, DIA, P(M)RM and intact mass spec)
* Drive the protein characterisation pipeline by applying various LC-MS based techniques for our lead biotherapeutic products
* Support the existing immunopeptidomic and proteomic activities including the discovery and validation of targets by LC-MS
* Provide input for continuous development of MS-based proteomics and immunopeptidomic methodologies by working cross-functionally with Enara's protein characterisation and computational biology teams
* Provide technical expertise supporting the maintenance and troubleshooting of the LC-MS instrumentation
* Analyse, interpret and clearly communicate data to various stakeholders to support discovery and validation campaigns
* Contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams
Minimum Qualifications and Experience required
* Ph.D. (or equivalent experience) in a relevant scientific discipline such as MS-based proteomics
* In-depth technical expertise in LC-MS based proteomics and related sample preparation
Experience & Key skills:
* A track record of working independently and with the ability to design and execute experiments supporting the characterisation of biologics (Peptide fingerprint mapping, PTM analysis, disulfide bridge mapping and host cell proteomics (HCP) analysis etc)
* Proven ability to develop and maintain high resolution LC-MS instrumentation and use of proteomics software tools (such as PEAKS, DIANN, Skyline etc)
* Demonstrated expertise using a relevant programming language (for example R) for data interrogation and analysis to support complex proteomics workflows and drive data‑driven decision‑making.
* Experience with sample preparation for proteomics analysis from biological samples including tissues and cell lines with knowledge of different enrichment strategies
* Effective communication, both written and verbal, with a good attention to detail
* Self-motivated and enthusiastic team player with experience of working in cross-functional teams and proven ability to work to specific deadlines
Desirable
* Experience of working with Bispecifics and/or mAb's would be advantageous
* Experience of LC-MS based immunopeptidomics
* Experience with developing and troubleshooting complimentary protein characterisation techniques (IEX, HIC, SEC)
* An understanding of the regulatory environment around biotherapeutics (ICH Q6B, ICH Q2 etc)
Further information:
The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:
Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability.
Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do.
Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego.
Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact.
We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance.
Applicants should be able to demonstrate proof of the right to work in United Kingdom.
Enara Bio Limited is an equal opportunities employer.