Alnylam Pharmaceuticals is seeking an imaginative physician drug developer to provide clinical leadership in developing RNAi therapeutics across its rapidly expanding portfolio, covering rare genetic diseases, cardio‑metabolic diseases, neuroscience, hematology and hepatology.
The successful candidate’s primary responsibility will be to drive the pipeline forward as a clinical lead physician on autoimmune liver disease programs, while also supporting a range of therapeutic areas and stages of development. The Senior Medical Director, Clinical Research will play a leading and influencing role in overall clinical development strategies, ensuring operational excellence across all associated trials.
The position is hybrid and will be primarily located at Alnylam’s Cambridge, MA headquarters or Maidenhead, UK location.
Key Responsibilities
* Provide strategic leadership and a clear voice for clinical programs.
* Develop creative yet realistic approaches to drug development and lead clinical efforts to secure global regulatory approvals.
* Oversee trial conduct and safety.
* Provide strategic consultation and guidance to research on decisions with significant clinical components.
* Collaborate closely with preclinical, regulatory affairs, medical affairs and commercial teams to ensure tight strategic integration of product development plans.
* Accountable via Clinical Research and Operations for all relevant timelines and deliverables.
* Drive and supervise all major written deliverables, including regulatory submissions, original articles, abstracts and presentation materials.
* Review and sign off all controlled documents, such as protocols, investigator brochures and informed consent forms, in line with SOPs.
* Influence internal and external audiences in a high‑impact, highly visible manner.
Qualifications
* MD with a strong research background or MD/PhD, with a track record of successful research support and peer‑review publications. Board certification (or equivalent) or specialist training is highly desirable; drug development experience in hepatology (autoimmune liver disease) advantageous but not essential.
* 5+ years of industry experience or equivalent clinical academic experience.
* Sound scientific and clinical judgment.
* Successful track record of leading Phase 2/3 clinical programs, including major interactions with health authorities.
* Familiarity with concepts of clinical research and trial design, including biostatistics, regulatory agency organization, guidelines and practices.
* Ability to effectively present ideas and communicate complex medical/clinical concepts in both written and oral formats.
* History of solving problems while exercising superior judgment and realistic understanding of issues.
* Outstanding leadership and collaboration skills within a matrix environment.
* Experience and knowledge of working with biotech/pharma partners is a plus.
* Thrives in a highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency.
Pay Range
£153,000.00 – £207,000.00 (base salary, subject to experience, skills and education). This role is eligible for annual short‑term and long‑term incentive awards.
Benefits
Alnylam’s total‑rewards package includes medical, dental and vision coverage, life and disability insurance, lifestyle reimbursement program, flexible spending and health savings accounts, a 401(k) with company match, paid time off, wellness days, holidays and recharge breaks, and generous family resources and leave.
Equal Employment Opportunity
Alnylam is an inclusive recruitment process and equal employment opportunity provider. Qualified applicants will receive consideration for employment without regard to sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.
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