About the role
We are seeking a highly motivated postdoctoral researcher to join this ambitious Prosperity Partnership between UCL and AstraZeneca and to work as part of a cross-disciplinary team across both sites (London and Cambridge). This role will contribute to the development of advanced digital twins for upstream bioprocessing, integrating real-time analytics and process analytical technologies (PAT) to accelerate innovation in biopharmaceutical manufacturing. The postholder will lead on the construction and application of mechanistic and hybrid digital twin models, capturing cell growth, nutrient consumption, and bioreactor dynamics for upstream processes. These models will be enhanced by the incorporation of real-time PAT data streams to enable predictive monitoring, dynamic process adjustments, and improved control strategies. Working closely with AstraZeneca, the postholder will apply these digital twins and sensors to real-world case studies of novel biologic modalities, evaluating how hybrid PAT–digital twin frameworks can optimise critical quality attributes, reduce development timelines, and de-risk scale-up.
This role is funded for 2 years in the first instance, with potential for extension.
About you
You will hold (or be near completion of) a PhD in a relevant discipline such as biochemical engineering, chemical engineering, process systems engineering, computer science, or a related field. You will bring expertise in digital twin development for upstream bioprocessing, with strong programming skills and practical modelling experience. Familiarity with the challenges of upstream biomanufacturing, including process analytical technologies (PAT) and advanced control strategies, would be desirable. You will have excellent communication skills and the ability to work both independently and collaboratively across teams and institutions. A commitment to UCL’s values and to promoting equality, diversity and inclusion is essential.
What we offer
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:
• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance