Join GSK as a Sterile Value Stream Director at the Barnard Castle site in County Durham, UK. This full‑time, site‑based leadership position is open until 15 Dec 2025 and offers an opportunity to drive transformational change in our sterile manufacturing operations.
Job Purpose
As Sterile Value Stream Director you will lead end‑to‑end sterile operations across the value stream, delivering a strategic transformation that moves the site from foundational rebuild to scale and excellence. You will ensure safe, compliant, and cost‑effective supply of sterile medicines to global markets, while creating and sustaining high‑performing management teams.
Key Responsibilities
* Define and execute the value‑stream strategy, translating global strategy into actionable site‑level plans.
* Unify manufacturing teams into an integrated, single‑team structure across sterile operations.
* Build and coach a high‑performing leadership team, setting clear roles, decision rights, and development plans.
* Drive change management, lean/CI initiatives, and foundational system rebuild to accelerate performance improvements.
* Lead digitalisation and AI strategy to enhance data‑driven decision‑making, predictive maintenance, and process control.
* Oversee end‑to‑end sterile processes (aseptic and terminal sterilisation, robotic filling, nano milling, cold chain) and champion productivity and throughput gains.
* Own quality, regulatory compliance, and safety across all sterile operations, meeting GSK and global regulatory standards.
* Define and track KPIs across people, safety, efficiency, quality, cost, and delivery, using insights to drive continuous improvement.
* Prioritise resource allocation, operational cost, and capital investments while ensuring financial stewardship.
* Maximise technology value (robotic filling, single‑use systems, HVLD, vacuum decay, RABS/CIP SIP, nano milling, eBRS) and ensure validation strategy meets modality‑specific needs.
* Collaborate with functional leaders across Quality, Regulatory, Engineering, Supply Chain, MSAT, Finance, and EHS, and with external suppliers and regulators.
* Lead leadership capability, succession planning, and a culture of inclusion and empowerment.
Technologies & Capabilities
* Aseptic filling—robotic VHP isolators, single‑use tech, peristaltic pumps.
* Terminal sterilisation—RABS filling lines, CIP/SIP, autoclaves.
* Inspection & leak detection—visual inspection, HVLD, vacuum decay.
* Packaging & assembly—automatic syringe assembly, labeling, carton packaging.
* Nano milling & cold chain—50L milling, high‑value biologics cold chain.
* Biologics‑specific—viral clearance, stringent contamination control.
* IT/automation—eBRS, process control, analytics systems.
Products Manufactured at the Site
* Large molecules—autoimmune, severe asthma, oncology.
* Monoclonal antibodies (mAbs)—oncology, autoimmune, other indications.
* Oligonucleotides—siRNA, antisense, related chemistries.
* Small molecules—migraine, influenza, HIV/AIDS prevention.
* Medium molecules—pulmonary arterial hypertension.
* Other advanced modalities also handled at the site.
Qualifications & Experience
* Bachelor’s degree in Business, Engineering, Operations, Supply Chain, Quality Management, or related field; Lean Six Sigma or PMP highly desirable.
* Substantial experience in sterile pharmaceutical manufacturing, leading large‑scale sterile operations and transformation programmes.
* Demonstrated ability to unify cross‑functional teams and drive change across complex organisations.
* Proven experience in leadership development, succession planning, coaching, and talent management.
* In‑depth technical knowledge of aseptic filling, RABS/VHP, HVLD, vacuum decay, single‑use systems, nano milling, eBRS and integrated automation; experience with biologics and oligonucleotides.
* Track record of implementing digitalisation and AI‑driven improvements in manufacturing environments.
* Strong record of driving compliance, regulatory readiness, and quality excellence across biologics modalities.
* Success applying lean methodologies and continuous improvement tools to deliver measurable operational improvements.
* Exceptional strategic thinking, stakeholder management, communication, and people development skills.
* Experience collaborating with global strategy teams and aligning site‑level plans with network‑level objectives.
Why this Role Matters
This transformational, highly visible role has significant strategic impact on GSK’s ability to supply life‑saving sterile medicines worldwide. The director will directly influence patient safety, product quality, and the long‑term competitiveness of the Barnard Castle site through bold leadership, technical expertise, and relentless focus on continuous improvement.
Equal Opportunity Employer
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
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