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Senior principal software engineer - r&d tech

London
Permanent
GSK
Principal software engineer
€75,000 a year
Posted: 26 January
Offer description

Location: UK – London – New Oxford Street, India - Karnataka - Bengaluru, USA - Pennsylvania - Upper Providence

Posted Date: Jan 19 2026

GSK remains committed to achieving bold commercial ambitions for the future. By 2031, we aim to deliver £40 billion in annual sales, leveraging our existing strong performance momentum to significantly increase our positive impact on the health of billions of patients globally. Our Ahead Together strategy is centered on early intervention to prevent and alter the course of disease, thereby protecting people and supporting healthcare systems.

Our diverse portfolio consists of vaccines, specialty medicines, and general medicines. Through continuous innovation and a dedicated focus on scientific and technical excellence, we strive to develop and launch new, groundbreaking treatments that address critical health challenges.


About R&D Technology

R&D at GSK is highly data‑driven, and we’re applying AI/ML and data engineering to generate new insights, enable analytics, gain efficiencies and automation. This role is in R&D Technology where you’ll architect and build production‑grade applications and data platforms. You’ll work on diverse projects spanning regulatory, clinical, legal and HR domains. Versatility is key, with an ability to quickly understand domain data and requirements and translate them into robust technical solutions. You will interact with architects, software and data engineers, AI/ML modelers, product owners as well as other team members across R&D. You will actively participate in creating technical solutions, designs, implementations and participate in the relentless improvement of R&D Tech systems in alignment with agile and DevOps principles.


In this role you will have the opportunity to work on a mixture of the following:


Software Engineering & Application Development

* Write production‑grade code for full‑stack applications using Python and modern frontend frameworks
* Build and maintain scalable REST APIs and microservices architectures
* Design application architectures and implement technical solutions
* Develop user interfaces and data visualization components
* Write comprehensive tests and ensure code quality
* Debug and optimize application performance


Cloud Architecture & Services

* Design and architect cloud‑native applications and solutions on Azure
* Leverage Azure services including App Services, Azure Functions, AKS, Storage, Data Factory, Cosmos DB
* Implement scalable, resilient, and cost‑effective cloud architectures
* Optimize cloud resource utilization and performance
* Design for high availability, disaster recovery, and security
* Implement cloud security best practices and governance


Data Engineering

* Build and maintain data pipelines for large‑scale data processing
* Implement ETL/ELT processes for diverse data sources
* Optimize data workflows and processing performance
* Design and implement data models and schemas
* Work with structured and unstructured data at scale


AI/ML & GenAI Integration

* Integrate AI/ML models and APIs into production applications
* Build GenAI applications using LLMs and frameworks like LangChain
* Implement RAG (Retrieval Augmented Generation) architectures
* Work with vector databases for semantic search capabilities
* Apply prompt engineering techniques for optimal LLM performance
* Understand and implement basic NLP tasks (text classification, entity extraction, embeddings)
* Collaborate with data scientists to productionise ML models
* Evaluate and integrate new AI/ML technologies


Database & Data Management

* Write SQL queries for data analysis and application needs
* Design and optimise database schemas for both relational and NoSQL databases
* Tune query performance and implement indexing strategies
* Implement data access patterns and ORM frameworks


DevOps & Infrastructure

* Implement Infrastructure as Code and CI/CD pipelines
* Containerise applications and orchestrate deployments with Docker and Kubernetes
* Implement monitoring, logging, and alerting solutions
* Automate deployment and operational processes
* Ensure application scalability and reliability


Cross‑team Collaboration

* Work closely with data scientists, engineers, and product owners across R&D
* Participate in code reviews and knowledge sharing
* Contribute to technical discussions and solution designs
* Identify innovations and architect solutions
* Evaluate and integrate new technologies


Basic Qualifications

* Bachelor's degree in Computer Science or equivalent relevant industry experience
* Significant hands‑on software development experience with demonstrated progression in technical complexity
* Expert‑level Python programming with extensive production application development experience
* Strong full‑stack development experience with modern frameworks (Backend: Python – FastAPI, Flask, Django; Frontend: React, Next.js, TypeScript or similar)
* Cloud services experience, preferably Azure (App Services, Functions, Storage or equivalent)
* Strong SQL skills: Writing complex queries, data modelling, and optimisation
* Data engineering fundamentals: Building data pipelines and working with large datasets
* Understanding of AI/ML concepts and practical experience (Familiarity with LLMs and GenAI applications; Basic understanding of how to integrate AI/ML APIs into applications; Knowledge of prompt engineering basics; Understanding of RAG architectures or willingness to learn quickly)
* Experience building production‑grade applications: Scalable, maintainable, well‑tested code
* Understanding of software architecture: Design patterns, microservices, distributed systems, cloud‑native architectures
* Version control with Git and collaborative development workflows
* DevOps practices: CI/CD pipelines, containerisation basics
* Agile development practices and iterative development
* Excellent problem‑solving and debugging skills
* Strong communication and collaboration skills
* Ability to quickly learn and adapt to new technologies


Highly Desired Skills

* Azure cloud platform expertise: Deep knowledge of Azure services (App Services, Azure Functions, AKS, Storage Accounts, Azure Data Factory, Cosmos DB, Azure SQL, Key Vault, Application Insights)
* Cloud architecture and design: Designing scalable, secure, and cost‑effective cloud solutions
* Databricks and Apache Spark for large‑scale data processing
* Hands‑on experience with GenAI platforms (OpenAI, Azure OpenAI, LangChain or similar)
* Experience building RAG applications with chunking, vectorisation, retrieval strategies
* Vector databases (pgvector, Pinecone, Weaviate or similar)
* DevOps maturity: Infrastructure as Code (Terraform, Bicep, ARM templates), advanced CI/CD
* Containerisation and orchestration: Docker and Kubernetes (AKS)
* Database expertise: PostgreSQL, SQL Server, Azure SQL with performance tuning
* Cloud security: Identity management, RBAC, network security, encryption
* Azure DevOps or GitHub Actions for CI/CD pipelines
* Experience with REST API design and microservices patterns


Preferred Qualifications

* Azure certifications (Azure Solutions Architect, Azure Developer, Azure Data Engineer)
* Advanced AI/ML knowledge (Experience with ML frameworks – TensorFlow, PyTorch, Hugging Face; Knowledge of model training and evaluation; Advanced NLP techniques; Experience with multi‑agent systems or advanced RAG patterns)
* MLOps knowledge: Model deployment, versioning, monitoring, A/B testing
* Azure AI services: Document Intelligence, Cognitive Search, Azure AI Studio, Azure Machine Learning
* Search technologies: Azure Search, Sinequa, Elasticsearch, Lucene‑based systems
* Advanced Spark optimisation and performance tuning
* Real‑time data processing and streaming architectures (Kafka, Azure Event Hubs)
* Pharmaceutical, healthcare, or regulated industry experience
* Experience with compliance requirements: HIPAA, GxP, 21 CFR Part 11
* Experience with data visualisation libraries (D3.js, Plotly, Chart.js)
* Software security best practices and secure coding
* FinOps practices: Cloud cost optimisation and management
* Experience mentoring junior engineers

Closing Date for Applications: Friday 30th January 2026 (COB)


Equal Opportunity Statement

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.


Adjustments to the Process

We encourage you to explore with our hiring team what the opportunities are for flexibility. If you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com. If your enquiry does not relate to adjustments we will not be able to support you through these channels. For further FAQs, see the Recruitment guide.

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