Reports to: Associate Director, Clinical Trial Business Operations
Position Summary
The Senior Manager, Clinical Trial Business Operations (CTBO) oversees CRO execution of investigator site budgets, contracts, site payments, and ICF deliverables. This role is also responsible for coordinating clinical trial insurance needs and supporting Sunshine Act/transparency reporting requirements. The Senior Manager ensures operational consistency, manages escalations, and contributes to compliance, quality, and governance activities.
Key Responsibilities
CRO Oversight
1. Review and oversee CRO work related to budgets, contracts, payments, and ICFs.
2. Ensure accuracy, quality, and alignment with internal templates, processes, and parameters.
3. Provide operational guidance to CRO teams to ensure consistency across regions and studies.
Escalation & Issue Management
4. Manage escalations exceeding CRO negotiation authority.
5. Partner with Clinical Operations, Finance, Legal, and other teams to resolve issues efficiently.
6. Document and communicate decisions to support timely study startup.
Clinical Trial Insurance Coordination
7. Intake and triage insurance requests and required inputs.
8. Work with Global Insurance & Risk Management to ensure appropriate coverage.
9. Track insurance progress and address issues affecting study activation.
Sunshine Act / Transparency Reporting
10. Collect, validate, and reconcile transparency‑related data.
11. Partner with Compliance to ensure accurate, timely reporting.
12. Support audit readiness for transparency‑reporting activities.
Compliance, Governance & Continuous Improvement
13. Apply and help maintain consistent ways of working with internal stakeholders and CRO partners.
14. Maintain audit‑ready records for budgets, contracts, insurance, and ICF decisions.
15. Monitor operational KPIs and highlight risks or process‑improvement opportunities.
16. Participate in operational reviews and governance forums.
Qualifications
Required
17. Bachelor’s degree in Business, Finance, Life Sciences, or related field.
18. Minimum 7 years’ experience supporting or overseeing site budgets, site contracts, and site payments within pharma/biotech or CRO environments.
19. Experience working within outsourced/CRO operating models.
20. Strong analytical, communication, problem‑solving, and organizational skills.
21. Ability to work cross‑functionally and manage multiple priorities.
Preferred
22. Experience with ICF processes, clinical trial insurance, and transparency reporting.
About CSL Behring
CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
CSL Behring operates one of the world’s largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.
To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit and CSL Plasma at .
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