We are seeking a highly motivated and technically strong postdoctoral researcher to investigate the molecular and cellular mechanisms linking genetic variation to appetite and obesity.
This role will focus on translating genetic discoveries into biological insight, using a combination of cell biology, molecular approaches, and functional assays.
Scientific Context
Our research programme uses genetic approaches in dogs and humans to identify novel genes influencing appetite and obesity risk. These discoveries provide a powerful entry point into previously unrecognised biological pathways.
This post will focus on understanding how these genes influence cellular and physiological processes, particularly in pathways relevant to energy balance, including neuronal signalling and adipose biology. The work forms part of a 5-year ERC-funded programme aimed at advancing fundamental understanding of obesity and informing improved approaches to prevention and treatment.
The Role
The successful candidate will lead experimental studies to define the function of genes and variants identified through genomic analyses.
This is an opportunity to develop and apply advanced molecular and cellular approaches to uncover mechanisms linking genotype to phenotype. The project is inherently exploratory and will involve adapting and developing experimental strategies as new findings emerge.
Responsibilities Will Include
* Designing and conducting functional experiments to investigate candidate genes;
* Using cell-based systems to study gene function, regulation, and signalling pathways;
* Applying molecular biology approaches (e.g. gene expression analysis, genome editing, reporter assays);
* Developing and adapting experimental systems in response to emerging hypotheses;
* Working closely with computational genetics colleagues to prioritise and interpret findings;
* Leading publications and contributing to the broader direction of the project.
The role offers significant scope to learn new techniques and approaches. We have a strong track record of establishing productive collaborations with specialists in complementary fields, particularly in cell biology, and actively support team members in building the expertise and partnerships needed to tackle new experimental challenges.
About You
We are interested in candidates who combine technical excellence with curiosity and a strong drive to understand underlying obesity biology.
You should have a PhD (or be near completion) in cell biology, molecular biology, neuroscience, metabolism, or a related field and strong experimental skills in molecular and/or cellular biology. The successful candidate should have experience designing and executing hypothesis-driven research and have the ability to analyse and interpret complex biological data. Please see the Further Particulars for more details on the requirements for the role.
Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.
Salary Ranges: Research Assistant: £33,002 - £34,610; Research Associate: £37,694 - £46,049
Informal enquiries can be made to Dr Eleanor Raffan er311@cam.ac.uk. Candidates interested in part-time or flexible working are encouraged to discuss this in advance of application.
Fixed Term: the funds for this post are available for 5 years in the first instance.
Apply
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
To apply for this post, please submit a CV, a motivation letter detailing why you want to be part of this project and how this post will be a good stepping-stone for your career. We also need the contact details for two people who can provide a professional reference. Please note that we will assume that you are happy for us to approach your referees at any stage, unless you indicate otherwise in the space provided on the form.
The closing date for applications is 29 May 2026. Interviews will be held on 5 or 8 June.
Please quote reference PM49600 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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