2 weeks ago Be among the first 25 applicants
Get AI-powered advice on this job and more exclusive features.
CANCER RESEARCH UK
200 staff. Limitless Potential. One team - Cancer Research Horizons.
Senior Scientist - Protein & Antibody Engineering - Under the leadership of Nick Tribble
Salary: £41,700 - £46,500 per annum (dependent on experience) plus benefits (includes up to 12% pension contribution and income protection)
Reports to: Group Leader, Antibody Discovery
Department: Research and Innovation
Contract: Permanent
Hours: Full time 35 hours per week (flexible working requests considered)
Location: Cori Building, Granta Park, Cambridge
Closing date: 27 April 2025 23:55 This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. If you require more time to apply as part of a reasonable adjustment, please contact as soon as possible.
Visa Sponsorship: Cancer Research UK is able to consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application.
Interview date: W/C 12 May 2025
At Cancer Research UK, we exist to beat cancer.
We currently have an exciting opportunity within our Drug Discovery team for an experienced Senior Scientist to expand and enhance our capabilities in therapeutic antibody discovery.
About CRUK Drug Discovery
As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs 200 staff from both industrial and academic backgrounds.
This is a great opportunity for a Protein Scientist, Protein Engineering Scientist or Antibody Engineering Scientist to expand their skill set across protein engineering, antibody screening & characterisation and protein science in a flexible environment with support from highly experienced colleagues from our multidisciplinary antibody discovery team. You will also have the opportunity to contribute to key pipeline and technology development projects and to showcase them to the wider organisation. We work in an inclusive environment where we welcome creative thinking and new ideas, and we would value your input on implementing new technologies and improving existing processes and infrastructure. We also actively encourage our colleagues to celebrate our science by attending conferences, presenting posters, giving talks at events, and publishing papers.
What will I be doing?
* Applying molecular biology techniques to enable protein expression and antibody drug discovery.
* Troubleshooting & designing solutions to drive innovative challenging drug discovery at pace.
* Sourcing, producing, designing, QC, and assessing antigens & reagents required for discovery cascade.
* Collaborating to drive design and optimisation of therapeutic antibodies.
* Evaluating potential drug targets and biological hypotheses.
* Supporting expression and purification of antibodies and fragments (scFv, Fab, VHH, IgG) from bacterial and mammalian hosts.
* Maintaining and operating state-of-the-art laboratory equipment.
* Potential line management of junior staff.
What skills will I need?
* Degree and/or PhD in relevant field.
* Experience in pre-clinical antibody drug discovery.
* Understanding of biotherapeutic candidate discovery and development.
* Experience with purified affinity tagged proteins and automated purification platforms.
* Knowledge of protein QC analysis techniques like SDS-PAGE, HPLC, Western blotting.
* Experience with molecular biology techniques for constructing and mutagenising expression vectors.
* Awareness of AI/ML benefits in antibody research.
* Ability to proactively drive research, prioritize, multitask, and adapt.
* Strong collaboration and communication skills.
* Experience with automated liquid handling and high-throughput assays is desirable.
* Knowledge of protein interaction measurements and informatic analysis is highly desirable.
What will I gain?
Our employees contribute significantly to our goal to beat cancer. We support your career and personal development with a generous benefits package, flexible working, and high-quality tools and policies. Our benefits include a substantial retirement plan, flexible leave, discounts, gym membership, and more. We promote a flexible working culture and a vibrant scientific environment where you can present your work at conferences and publish papers.
How do I apply?
We use an anonymised shortlisting process to promote equality, diversity, and inclusion. CVs are required but only reviewed after interview invitations are sent. Please complete the work history section of the online application form for fair assessment.
#J-18808-Ljbffr