Hours per week 37 Project Title Exploiting the TraDIS-Xpress platform to identify unexplored and essential intracellular targets for MDR invasive Salmonella
Months Duration 18 Interview Date 23 May 2025
Job Description
Main Purpose of the Job
To create transposon mutant library in Salmonella as part of a collaborative project with TCOLF and to use this library to screen a panel of antimicrobials to identify modes of action
Key Relationships
Mark Webber (Line manager)
Postdocs within the Webber group (in particular Emma Holden who is working on a similar project)
Students within the group as a source of advice and support
TCOLF staff as collaborating partner organisation
MFS management
Other QIB groups
Main Activities & Responsibilities
Percentage To create transposon mutant libraries as required by the project in Salmonella 30 To perform experiments to identify genes under selective pressure from novel antimicrobials 20 To sequence DNA libraries and analyse data 20 To prepare presentations and reports from the data generated 10 To liaise with external stakeholders 10 To contribute to laboratory and group management 5 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5
Person Profile
Education & Qualifications
Requirement Importance PhD in relevant subject Essential BSc in relevant subject Essential
Specialist Knowledge & Skills
Requirement Importance Familiarity handling bacterial pathogens Essential Strong molecular microbiology expertise Essential Familiarity with bacterial genomics Essential Experience with cell culture Desirable
Requirement Importance Experience in a laboratory setting working with bacterial pathogens Essential Experience making mutants/cloning etc Essential Ability to analyse genome sequences from bacteria Essential Hands on experience with tissue culture Desirable Experience working with multiple stakeholders Desirable
Interpersonal & Communication Skills
Requirement Importance Proven history of scientific writing Essential Good communication skills, both written and verbal Essential Good interpersonal skills, with the ability to work well as part of a team Essential Strong record keeping Essential Promotes and strives for continuous improvement Essential
Additional Requirements
Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to work outside standard working hours when required Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential
Who We Are
Quadram Institute Bioscience
The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.
We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.
The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.
The candidate will join the Webber group which is embedded within the MFS ISP within QIB and consists of multiple postdocs and PhD students studying different aspects of bacterial adaptation
Research Scientist
Applications are invited for a Research Scientist to join the Laboratory of Dr Webber in the Microbes and Food Safety programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.
Background:
The candidate will join the Webber group which is embedded within the MFS ISP within QIB and consists of multiple postdocs and PhD students studying different aspects of bacterial adaptation
The role:
This post represents an opportunity to join an exciting project to help develop novel antimicrobials using high throughput transposon mutagenesis to help understand mechanisms of action and resistance.
The candidate will join the Webber group within the Quadram Institute and have opportunities to develop their skillset within a vibrant and supportive environment.
Main duties for this role will include:
•Performing experiments to identify genes under selective pressure from novel antimicrobials
•Sequence DNA libraries and analyse data
•Prepare presentations and reports from the data generated
The ideal candidate:
Candidates should have a PhD in microbiology/ genomics and experience working with bacterial pathogens. It is advantageous if the candidate has experience with cell culture and in working with multiple stakeholders.
Good communication skills and the ability to work independently and in teams are required.
Additional information:
Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post with an expected end date of 16 March 2027.
This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.
Interviews will be held on 23 May 2025.
We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
About the Quadram Institute:
The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park. This is one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/ ).
The closing date for applications will be 5 May 2025
The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.
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