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We are a growth-stage pharmaceutical R&D company focusing on AI-driven drug discovery and advanced formulation development. We are looking for a Prodrug Evaluation Consultant with proven expertise in medicinal chemistry and DMPK to assess the chemical feasibility, bioconversion mechanisms, and clinical viability of early-stage prodrug candidates. This consultant will help validate internal and external assets by guiding molecule selection, evaluating risk–benefit profiles, and recommending data-driven strategies for advancement or termination. This project will start out at 10hrs/wk for 6 months with the possibility of extension.
Responsibilities
* Evaluate the chemical rationale and synthetic feasibility of candidate prodrugs, including promoiety selection and cleavage mechanism.
* Assess the bioconversion kinetics and likely in vivo activation using in vitro and preclinical species data.
* Analyze and interpret physicochemical and PK/PD data (solubility, permeability, stability, clearance, bioavailability) to determine viability.
* Predict human exposure and activation profiles through IVIVE and PBPK modeling using relevant tools (e.g., Simcyp, GastroPlus).
* Review or advise on in vitro metabolism, metabolite ID, and bioanalytical assay development for parent/prodrug/active species.
* Guide the design of preclinical studies (PK, efficacy, tox) to support proof-of-concept and IND-enabling work.
* Support regulatory strategy by contributing to technical rationales, briefing documents, and responses related to prodrug justification.
* Advise internal teams and external partners on whether to prioritize, redesign, or deprioritize specific prodrug approaches.
Ideal Candidate
* The ideal candidate is a pharmaceutical scientist with a PhD in Chemistry, Medicinal Chemistry, Pharmaceutical Sciences, or Chemical Biology and some industry experience, including advancing prodrug candidates through preclinical and IND-enabling stages.
* Grasp of chemical stability, enzymatic activation, and PK modeling across species, as well as experience with bioanalytical and metabolite ID methods.
* Both a strategic thinker and technically hands-on—capable of integrating chemistry, DMPK, and early safety data to support go/no-go decisions.
* Experience with PBPK platforms (e.g., Simcyp, GastroPlus), IND submissions, and regulatory interactions related to prodrug strategies is preferred.
Seniority level
* Seniority level
Associate
Employment type
* Employment type
Contract
Job function
* Job function
Consulting
* Industries
Pharmaceutical Manufacturing and Biotechnology Research
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