Lead Bioprocess Engineer – Scale-Up & Pilot Operations
Location: Somerset, UK (site-based)
Type: Full-time
We are seeking an experienced Lead Bioprocess Engineer to lead the scale-up and industrialisation of an experiments, troubleshooting processes, and optimising performance.
Key responsibilities include:
* Leading end-to-end scale-up activities, from bench through pilot-scale demonstration
* Translating cell culture and tissue engineering processes into scalable manufacturing solutions
* Taking a hands-on role in process optimisation, troubleshooting, and system improvements across both unit operations and the wider platform
* Designing and overseeing scale-down models and experimental plans to support robust scaling strategies
* Driving improvements in process efficiency, cost of goods, and environmental performance
* Ensuring appropriate process documentation, validation, and technical standards are maintained
* Collaborating with internal teams and external partners to support technology development and delivery
* Managing and developing a team of engineers and scientists (3–5 direct reports)
About You
You will bring a strong combination of technical depth, practical experience, and leadership capability, with a clear track record in bioprocess scale-up and industrial biotechnology.
Key requirements:
* Advanced qualification in bioprocess, biochemical, or chemical engineering
* Extensive industry experience in bioprocess development and scaling
* Proven track record working with bioreactors and associated unit operations from bench to pilot scale
* Strong understanding of upstream and/or downstream processing, including troubleshooting and optimisation
* Experience with CIP/SIP, contamination control, and operational challenges in bioprocess environments
* Demonstrated experience in leading teams and delivering complex technical programmes
* A practical, hands-on mindset, comfortable working directly with equipment and processes on-site
* A proactive, can-do attitude, with the ability to solve complex problems and adapt in a fast-paced environment
Why Apply?
This is an opportunity to play a central role in scaling a novel bioprocess technology, combining technical leadership with hands-on engineering and science. You will work in a collaborative, innovation-driven environment where your experience will directly influence the transition from R&D to real-world production.
If you are a technically strong bioprocess expert who enjoys being close to the process, leading teams, and delivering scale-up in practice, this role offers a highly impactful next step.