Overview
Clinical Trial Manager role at University of Oxford
We are seeking an experienced Clinical Trial Manager to support DEN-HOST, a large randomised adaptive phase 3 trial evaluating therapeutics for patients hospitalised with moderate or severe dengue. This post will be based at Big Data Institute, Li Ka Shing Centre for Health and Information Discovery, Old Road Campus, Headington, Oxford, OX3 7LF.
The trial aims to identify safe and affordable treatments that prevent disease progression in high-risk patients and improve outcomes for those with established severe disease, thereby reducing the burden on health systems in dengue-endemic regions. DEN-HOST will initially test three host-directed therapeutics and aims to recruit up to 8,000 patients across 25 sites in Peru, Colombia, Brazil, Bangladesh, Indonesia, Malaysia, Cambodia, Thailand, Nepal and Vietnam over five years. It will build on established networks including RECOVERY, ISARIC, PREPARE and OUCRU.
Responsibilities
* Lead trial set-up, including the establishment of Regional Coordinating Centres (RCCs) and governance and operational frameworks.
* Deliver ongoing trial delivery and oversight once recruitment begins; act as the primary operational contact for RCC leads.
* Monitor enrolment and trial conduct; coordinate protocol amendments; ensure governance and regulatory compliance; oversee trial documentation.
* Provide leadership within the Central Coordinating Office, including line-management of a Clinical Trials Assistant.
* Foster efficient and collaborative working practices across all partners.
Qualifications
* Degree in a biomedical or related subject, or other relevant qualification or proven experience in clinical research; substantial experience in international clinical trial set-up and delivery.
* Strong knowledge of ethics applications, Sponsor approvals, Clinical Trial Agreements, due diligence, and risk and governance frameworks.
* Experience managing multi-partner budgets and reporting; excellent communication skills; ability to work across multi-disciplinary, multi-country teams; prior line-management experience.
Application Process
Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.
Contract and Selection Details
This position is offered full time on a fixed term contract until 30 September 2027 and is funded by Wellcome. Interviews will be held on week commencing 17 November 2025. Only applications received before 12 midday on Wednesday 5 November 2025 will be considered. Please quote 182438 on all correspondence.
Location
Big Data Institute, Li Ka Shing Centre for Health and Information Discovery, Old Road Campus, Headington, Oxford, OX3 7LF.
Seniority level
* Associate
Employment type
* Full-time
Job function
* Management and Project Management
Industries
* Higher Education and Research Services
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