Job Description Job Summary: We are seeking a highly skilled and motivated In Vitro ADME Principal Scientist to join our dynamic team. The successful candidate will play a key role in supporting drug discovery and development programs by providing expert scientific and practical input into in vitro ADME (Absorption, Distribution, Metabolism, and Excretion) assays. This position requires a strong background in ADME & DMPK science, hands-on experience of assay development, and the ability to supervise and mentor junior staff to drive innovation and continuous improvement. Key Responsibilities: Provide expert practical and scientific support for a range of in vitro ADME assays to characterize candidate drug molecules. Design, develop, and optimize both existing and new automated in vitro assays to meet project needs. Train, mentor, and provide oversight to junior staff, fostering their scientific and technical growth and ensuring high-quality work. Conduct quality control and data review for in vitro assays to ensure accuracy and reliability. Author expert non-clinical study reports to support candidate nominations and regulatory submissions. Analyze and interpret in vitro data, providing clear and concise communication of results to project leads and stakeholders within agreed timelines. Collaborate with cross-functional teams to ensure alignment of in vitro DMPK activities with project goals. Maintain awareness of advancements in ADME/DMPK methodologies and technologies, applying innovative approaches to improve assay performance and efficiency. Education & Experience: Bachelor’s degree (BSc) plus a post-graduate qualification in a DMPK-relevant discipline and/or extensive experience of in vitro ADME assay development and data interpretation. Extensive scientific knowledge of ADME principles Proven experience of in vitro assay development and operation within a drug discovery environment. Demonstrated ability to work independently, delivering high-quality results within tight timelines. Strong organizational skills with the ability to prioritize workloads and adapt to changing project requirements. Key Skills & Competencies: Expertise in in vitro ADME assays and their application in drug discovery. Proficiency in automated assay systems and assay optimization. Strong analytical and problem-solving skills for data interpretation and troubleshooting. Excellent communication skills, with the ability to present complex data clearly to diverse audiences. Leadership and mentoring abilities to guide and develop junior team members. Attention to detail and commitment to maintaining high-quality standards in data generation and reporting. Adaptability and flexibility to manage shifting priorities and project timelines. LI-onsite; LI-SG-1 Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com