Consultant Call - DMPK (Peptide Therapeutics)
Constructive Bio is seeking an experienced DMPK or PK/PD (preclinical pharmacology) consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now.
Scope of work:
* Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
* Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
* Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
* Analyse data, highlight risks, and recommend next steps to guide project teams.
* Benchmark against industry best practices and prepare input suitable for preclinical packages.
* Support vendor/CRO selection and study oversight.
Requirements:
* Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
* Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
* Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
* Strong communication skills to work with internal scientists and external partners.
Desirable:
* Experience of in vitro and in vivo safety and toxicology studies
* Knowledge and preparation of IND documents would be an advantage
We are open to short- or medium-term consulting arrangements.
Please note that we work in a dog-friendly office