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Join to apply for the Principal Bioinformatician, CANCER RESEARCH UK role at Guardian Jobs
200 staff. Limitless Potential. One team - Cancer Research Horizons.
Principal Bioinformatician (Under the leadership of Alex Kalinka)
Starting salary in the range of £62K to £68K, dependent on experience plus benefits (includes up to 12% pension contribution and income protection)
Reports to: Group Leader
Directorate: Research & Innovation
Contract: Permanent
Hours: Full time 35 hours per week
Location: Cambridge, Functional Genomics Centre, Biomedical Campus (Limited flexibility 3-4 days per week on site)
Closing date: 12 May 2025 23:55
This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Please let us know if there is anything about the recruitment process that you would like to discuss, in particular if there are any changes or adjustments that would make it easier for you to apply. Please contact or 020 3469 8400 as soon as possible.
Visa sponsorship: Cancer Research UK can consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application.
Recruitment process: Screening call followed by competency-based interview and pre prepared presentation
At Cancer Research UK, we exist to beat cancer.
Cancer Research Horizons are looking to recruit a passionate individual to lead and drive our computational strategy for the analysis of large-scale genetic perturbation screens at the Functional Genomics Centre (FGC). This is an exciting opportunity and time to join us as we enter the next phase of our renewed FGC collaboration with AstraZeneca, housed in their Discovery centre (DISC) building on the biomedical campus in Cambridge.
About Cancer Research Horizons
As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs approximately 200 staff from both industrial and academic backgrounds.
What will I be doing?
Our new strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical Candidate. Reporting directly to the Leader of our Quantitative Biology team, you will line manage 1+ Bioinformaticians setting the vision and leading our computational strategy for the analysis of large-scale genetic perturbation screens, helping to identify and implement quantitative approaches to address key biological questions.
As our Principal Bioinformatician, you will be a creative and solution-oriented scientist with a proven record of bringing your knowledge of computational biology to impact on functional genomics projects preferably in a drug discovery context. You will be a confident scientific leader, able to represent the department across a broad range of long and short term projects both internally and through external collaborations (both academic and commercial). You will strengthen our computational approaches working in a cross-disciplinary environment alongside bench scientists, software engineers, and project managers. A significant element of the role will involve matrix leadership; you will also play a pivotal role in training and developing colleagues.
This is a great opportunity to leverage cutting-edge techniques such as CRISPR single-cell perturbation screens (Perturb-seq) and in vivo CRISPR screenings to analyse gene function. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers. In this role you will become an integral part of the Cancer Research Horizon Drug Discovery team helping to progress novel cancer targets towards patient benefit.
What are you looking for?
We are seeking an accomplished scientific leader who can set and drive our functional genomics strategy to help discover novel therapeutics in the oncology space.
Requirements include a PhD in bioinformatics, data science, or equivalent drug discovery experience, proven scientific leadership, deep expertise in computational biology, experience with NGS data analysis, programming in R and Python, querying SQL databases, and a track record of scientific delivery and external publications. Experience with machine learning or AI tools would be an advantage.
Our organisation values are designed to guide all that we do: Bold, Credible, Human, Together. We seek individuals who embody these values to drive progress against our mission to beat cancer.
If you're interested in applying but unsure if you have the right skills, we still encourage you to apply.
What will I gain?
We offer a supportive working environment, generous benefits, career development opportunities, and tools to help you achieve your personal wellbeing goals. Visit our careers web page to explore our benefits.
How do I apply?
We operate an anonymised shortlisting process to promote equality, diversity, and inclusion. CVs are required but not viewed until interview; we ask you to complete the work history section of the online application form. For more information, visit our website or contact us. Follow us on LinkedIn, Facebook, Instagram, X, and YouTube for updates.
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