Overview
Associate Director, Translational Lead (Hepatology). The Respiratory, Immunology and Inflammation (RII) Translational Unit (RIITU) within RII Research Unit (RIIRU) is accountable for end-to-end disease area translational science to inform therapy area and program-level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support PoM, signs of clinical efficacy, PoC, and pairing MOAs with patient subtypes to predict responder populations.
Note: Depending on candidate experience, this position may be considered at Grade 6 or 7.
Responsibilities
* Lead and/or contribute to developing innovative translational strategies in Hepatology for assets ranging from preclinical to clinical stage of development.
* Develop biomarker strategies aligned with clinical development plans to generate data that informs target engagement, pharmacodynamics, mechanism of action and patient stratification/selection.
* Represent RIITU at Early Development Team (EDT), Clinical Matrix Teams (CMT) and clinical trial study teams (ST). As part of the CMT and clinical ST, establish clear decision-making criteria to enable biomarker-informed clinical decisions.
* Provide input on biomarker-related elements of clinical study documentation for study start and reporting of biomarker data generated from clinical trials.
* Provide scientific expertise and technical guidance to enable timely biomarker sample collection and analysis including high-dimensional assays to deliver high-quality biomarker data packages to inform clinical development, integrated evidence plan and regulatory strategy.
* Collaborate with cross-functional teams including biology, translational disease teams, human genetics and genomics, clinical, medical affairs to ensure end-to-end biomarker data generation for asset needs and reverse translation to support the pipeline.
Basic Qualifications & Skills
* Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field).
* Experience in translational science and biomarker development in a clinical trial setting within the pharmaceutical or biotechnology industry.
* Knowledge and understanding in translational/biomarker development and implementation.
* Experience of working in a clinical trial setting, part of a clinical study team, and experience of authoring and oversight of clinical and regulatory documents.
* Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
* Experience in managing external collaborations with academic partners and CROs.
* Strong interpersonal, matrix leadership and communication skills as well as ability to thrive in a matrix environment.
Preferred Qualifications & Skills
* Demonstrated scientific capability as evidenced by publications, research reports, and external presentations.
* Up-to-date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
* Experience with novel technologies e.g., spatial transcriptomics and AIML.
* Knowledge and expertise in Fibrosis and ECM Biology.
* Knowledge and experience in Steatotic Liver Disease (SLD).
Closing Date for Applications – 14 September 2025 (COB).
Please apply with a cover letter and/or CV describing how you meet the competencies as outlined in the job requirements above. The information provided will be used to assess your application.
GSK is an Equal Opportunity Employer. See the full notice in the original posting for details on protections against discrimination and accommodations. For adjustments to the application process, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391 (hours apply).
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