<div><h3>Job Title</h3><p><b>Senior Scientist I (Membrane Protein Biochemist)</b></p><h3>Job Type</h3><p><b>Permanent</b></p><h3>Location</h3><p>Alderley Park, Macclesfield, SK10 4TG</p><h3>Overview</h3><p>We are seeking a highly capable and motivated scientist to join our membrane protein production team. The ideal candidate will bring significant expertise in membrane protein biochemistry & biophysics and have a good understanding of small molecules and/or biologics drug discovery. Through lab-based leadership, you will be responsible for the execution of multiple discovery projects.</p><h3>Key Accountabilities</h3><ul><li>Design and execution of agreed work plans for the production and characterization of membrane proteins.</li><li>Responsible for supporting multiple projects and may be asked to direct internal resources to achieve agreed goals.</li><li>Will be expected to provide oversight of results to ensure quality to project specifications.</li><li>Accountable, together with project counterparts, for the design of experiments, review of documentation, and client presentations. Will conduct thorough data analysis ahead of product release to internal or external customers.</li><li>Proposes experimental designs and novel approaches to identify/advance best strategies in addition to planning/executing project deliverables.</li><li>Responsible for the implementation of standalone scientific services and deliverables to customers.</li><li>Where responsible for reports, will lead colleagues to co‑develop plans for personal growth, aligned to business needs.</li><li>Represent the company at scientific and/or business conferences.</li><li>Presents and publishes as appropriate peer‑reviewed science, increasing own and Evotec’s scientific reputation.</li></ul><h3>Knowledge & Experience</h3><ul><li>Comprehensive knowledge of membrane protein biochemistry & biophysics with a proven ability to design and deliver results within agreed timelines and budget, meeting agreed quality criteria.</li><li>Experience in the design of membrane protein constructs to optimise functional expression in eukaryotic expression systems.</li><li>Extensive hands‑on experience with insect and mammalian cell expression systems and multi‑step chromatography purification. Proficiency with FPLC/HPLC purification systems. Analytical UHPLC experience is a plus.</li><li>Expert in the optimisation of protein expression and purification workflows to obtain pure and stable membrane protein samples.</li><li>Demonstrated success working with challenging membrane protein targets e.g. G protein‑coupled receptors (GPCRs), ion channels, solute carriers, and integral membrane enzymes. A good understanding of different modalities (e.g. agonist/antagonist for GPCRs, blockers/activators for ion channels) across multiple therapeutic areas would be desirable.</li><li>Experience with biochemical and biophysical characterization of purified membrane proteins using a range of techniques such as fluorescence size‑exclusion chromatography (fSEC), DLS, nanoDSF, mass spectrometry, SPR, GCI, and microcalorimetry.</li><li>Extensive knowledge of what constitutes a good membrane protein sample for structural (X‑ray crystallography and/or cryo‑EM) and biophysical studies (SPR/GCI, HDX‑MS).</li><li>Experience in the solubilization and stabilization of membrane proteins into co‑polymers (e.g. Amphipols, Cubipols).</li><li>Experience in developing protein binders (Fabs, VHHs, synthetic binders) for complex targets would be advantageous.</li><li>Experience in high‑throughput methodologies with associated data capture and handling.</li><li>Experience with using in silico‑based tools for sequence and structural analysis is desired (e.g. PyMOL, AlphaFold).</li><li>Experience in preparing and executing work plans and building trusted partnerships with internal and external customers.</li><li>Requires a track record of leading scientists across specialist fields.</li><li>A track record of facilitating employee growth through co‑development of personal development plans would be appreciated.</li><li>Track record of successful problem‑solving, high‑quality science and influencing stakeholders and colleagues.</li><li>Experience of scientific development and research work, ideally with publications on membrane proteins.</li><li>Presents and publishes as appropriate peer‑reviewed science, increasing own and Evotec’s scientific reputation.</li></ul><h3>Education And Qualifications</h3><p>PhD in Biochemistry, Biophysics, Structural Biology or similar, with proven experience in membrane protein expression and purification with relevant experience within industry. Alternatively, a relevant first degree and several years of additional experience in drug discovery. <b>Candidates with strong academic background and an excellent publication record are also encouraged to apply.</b></p><h3>Evotec Leadership Competencies</h3><ul><li><b>Active Communication:</b> Communicates actively, working on further clarity and responsiveness.</li><li><b>Constructive Feedback:</b> Actively seeks and provides constructive feedback, using it to improve processes and outcomes.</li><li><b>Consistent Team Engagement:</b> Engages frequently, fostering a more positive and collaborative environment.</li><li><b>Foundational Direction Sharing:</b> Communicates pragmatic directions, leading to general understanding and alignment.</li><li><b>Occasional Planning:</b> Begins anticipating problems and improves on proactively taking precautions.</li><li><b>Effective Delegation:</b> Delegates tasks effectively, trusting team members to handle responsibilities and providing necessary support and development.</li></ul><h3>Benefits Package</h3><ul><li>Pension on completion (but not subject to) of your 3‑month probationary period. Contributions 5% for employees (salary sacrifice) and 5% for the employer. The employee can opt to increase their contribution, and the employer will match the increase up to a maximum of 7.5%.</li><li>25 days holiday plus bank holidays and additional length of service days awarded on the anniversary, up to a maximum of 30 days.</li><li>Private health insurance with BUPA for the employee and their partner/family under the company scheme.</li><li>Well‑being support 24/7 and counselling services.</li><li>Permanent health insurance provides 75% of the base salary after the qualifying period.</li><li>Private dental cover, on completion (but not subject to) of your 3‑month probationary period.</li><li>Eligibility to participate in the Company Bonus Scheme. This is a discretionary benefit.</li><li>Career progression within the company, we have excellent training and support and continuing professional development opportunities.</li><li>Cycle‑to‑work scheme.</li><li>Refer a friend scheme, team and annual events, recognition awards and many more!</li></ul><h3>Onsite Facilities</h3><ul><li>The company pays for secure onsite parking.</li><li>Restaurant, Café, and Gastro pub.</li><li>Gym and workout studio, running, walking, and cycling routes.</li><li>Good public transport links with the shuttle bus service.</li></ul><p>Please note closing date for all applications will be Thursday 9th July 2026</p><p>We may close this earlier depending on the number of applications received.</p><p>FR : Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.</p><p>ENG : In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.</p></div>