We are looking for a talented and motivated postdoctoral scientist to join the lab of Professor Sir Steve Jackson, based in the internationally renowned Cancer Research UK Cambridge Institute, located on the Cambridge Biomedical Campus, Cambridge, UK. Targeted radioligand therapy (TRT) is developing rapidly as a cancer treatment, yet the molecular and cellular mechanisms that shape tumour sensitivity and resistance to alpha and beta emitting TRT agents and how these mechanisms may be leveraged for therapeutic benefit are still not fully defined. This project will investigate the fundamental biological determinants of responses to TRT agents, with the aim of identifying predictive biomarkers and developing rational combination strategies to enhance treatment efficacy.
The Postholder Will
* Design and conduct CRISPR screens in human cancer cell models to identify genetic drivers of sensitivity and resistance to alpha and beta emitting TRT agents.
* Characterise how alterations in DNA damage response (DDR) pathways and associated cellular processes influence responses to TRT agents.
* Generate multiple gene knockouts, inducible expression systems, and related approaches to investigate the functional roles of candidate targets in the context of radioligand exposures.
* Carry out follow‑up validation and mechanistic studies, including analyses of DNA damage signalling, cell survival assays, imaging based assays, and additional CRISPR screens, to fully characterise novel genetic and functional relationships.
* Undertake specialist training and certification for work with radioactive materials.
Essential Criteria
Candidates are expected to be comfortable with working collaboratively, intellectually independent and highly motivated and must have a PhD in biological sciences or be close to completing their postgraduate degree. Candidates should have strong experience in mammalian cell biology. A background in ionising radiation, DNA damage/repair as well as an understanding of CRISPR‑Cas9 technologies are desirable. Some knowledge of bioinformatics is also desirable. Applicants should have excellent written and spoken English communication skills and demonstrate excellent strong attention to detail and organisation. Applicants will play a key role in a large, vibrant and interactive research group, so a collaborative, friendly and collegial attitude is essential.
The position offers a competitive salary, and the successful candidate will enjoy the diverse, vibrant and highly supportive research environment of the CRUK Cambridge Institute and the University of Cambridge.
Fixed‑term: The funds for this post are available for 2 years in the first instance.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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