Overview
Our client, an innovative Biotechnology business, is seeking a Scientist - Target Validation and Drug Screening to join their team based in Cambridge. As the Scientist - Target Validation and Drug Screening, you will play a pivotal role in advancing treatments for rare neurological disorders, including neuro-oncology.
Responsibilities
* Prioritise and triage drug and CRISPRi screen hits using literature, pathway analyses, public datasets, and internal context.
* Formulate testable hypotheses and design validation cascades with clear go/no-go criteria and timelines. Execute orthogonal genetic validation.
* Develop and qualify robust cell-based assays aligned to target biology and mechanism of action in 2D systems (3D preferred). Define and implement control strategies, plate and sample randomisation and batch-effect controls.
* Integrate genetic and pharmacological perturbations to probe mechanism and pathway placement.
Requirements
* Relevant degree in a biological science, ideally PhD, with proven industry experience in early target discovery and validation.
* Proficiency in high-content imaging, flow cytometry, qPCR or equivalent molecular assays; strong mammalian cell culture skills.
* A working knowledge and practical experience with CRISPR-based perturbation modalities and cell-based assay development.
Keywords
* Scientist
* Target Validation
* Drug Screening
* CRISPR
* Cell-based Assays
* Biotechnology
* Cambridge
* Neuro-oncology
* Genetic Epilepsies
* Neuropathic Pain
* Demyelinating Diseases
About Hyper Recruitment Solutions
Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer. We welcome applications from anyone who meets the role requirements.
Job details
* Seniority level: Entry level
* Employment type: Full-time
* Job function: Research, Analyst, and Information Technology
* Industries: Biotechnology; Pharmaceutical Manufacturing
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