Research Associate II, In Vivo
Apply locations
Edinburgh, UK
Time type: Full time
Posted on: Posted 25 Days Ago
Job requisition id: R25-27
Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.
At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.
We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, Germany, and Spain.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:
* Advance innovative science by pushing boundaries.
* Bring transformative therapeutics to patients in need.
* Provide an environment for employees to reach their fullest potential.
Our values:
* Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
* Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
* Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
* Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
* Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.
Position Summary
Reporting to the in vivo manager, you will provide support in running downstream analysis of animal studies on site. This is a hands-on role with significant responsibility, requiring performing molecular biology assays at high throughput, performing immunohistochemistry protocols, and conducting procedures on animals.
Job Responsibilities
* Perform molecular biology techniques such as qPCR, RT-PCR, DNA/RNA extractions and protein assays at high throughput.
* Perform immunohistochemical techniques such as tissue processing, sectioning, antibody staining and imaging.
* Perform procedures with animals, such as dosing and tissue dissections.
* Process, analyze, and present data.
* Deliver quality work within project timelines.
* Manage workload with minimal supervision.
Minimum Requirements
* Bachelor’s degree in biology, chemistry, or related field with 2+ years’ related experience.
* Motivated to learn and develop new techniques.
* Enthusiastic and positive attitude.
* Ability to present data confidently and clearly, both verbally and through written reports.
* Experience of working with rodents.
* Strong organizational and planning skills.
* Demonstratable skills in histology including cryosectioning and immunofluorescence.
* Demonstratable skills in molecular biology.
Preferred Skills & Abilities
* Experience in molecular biology, particularly qPCR, RT-PCR, DNA/RNA extractions.
* Experience of working with rodents, including RoAs: IV, PO, IP, SC, IM.
* Experience with cryosectioning, microtomy and immunohistochemical techniques.
* Experience in microscopy desirable but not essential.
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