If you are a current Jazz employee please apply via the Internal Career site.
Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information.
This role requires you to be onsite full time based at our site on Kent Science Park in Sittingbourne.
Brief Description:
The Associate Director, R&D – Process Chemistry heads the process
research and
development team within the Discovery and Medicinal Chemistry group at Kent Science Park,
adopting a leadership and technical role and
working together with other CMC functions to advance drug candidates from lead optimisation to GLP Tox.
Essential Functions
Lead a group of scientists and is accountable for the development activities in the
Process Development Tea
m.
Analyse
Evaluate
medicinal chemistry synthetic procedures to redesign and
/or
identify
scalable processes covering supply of early development activities
up to GLP Tox
.
Plan, agree,
resource
and execute the optimization of a synthetic route
identifying
clear deliverables and milestones in accordance
to
with
the overall molecule project plan.
Identifies
intellectual property generation opportunities and drives innovation within the team.
Presents regularly
project updates to the department and CMC teams
with a clear focus on prioritization
and delivery.
Acts as the Drug Substance Lead and SME, working closely with other
early CMC
functions
as
including
analytical,
preformulation
,
biopharmaceutics
Medicinal Chemistry
and toxicology.
Promotes a
purpose driven
team environment
, with a focus on safety within the department
.
Identifies
procedural
and technical
gaps within the department and drives implementation of optimized procedures.
Required Knowledge, Skills, and Abilities
Relevant pharmaceutical industry experience within a Discovery/Early Development setting with a broad theoretical and practical understanding of early drug developmen
t and drug candidate nomination criteria.
Good understanding of the
key
attributes that make a potential drug suitable for
IND-enabling /
clinical development.
Scours relevant scientific literature within field and surveys broadly beyond own discipline/field.
Excellent management skills, including planning and resource allocation.
Excellent verbal and written communication skills, including the ability to communicate
effectively
with external partners.
Strong IT skills and an ability to use key software packages to produce, present and
analyse
data and produce compelling materials for internal and external use
Demonstrated ability to
lead projects
from
inception
to completion, coordinating the efforts of
a team
within budget,
timelines
and regulatory requirements.
Partner with
P
harmaceutical
D
evelopment on
API development
approaches to mitigate risk as candidates progress
.
Displays the attributes encompassed in Jazz’s values and encourages their development in others.
Required/Preferred Education and Licenses
MSc/PhD in a
chemical or pharmaceutical subject
, ideally with postgraduate qualification in chemical synthesis, drug substance development or related discipline.
Knowledge of quality and regulatory standards within the Pharmaceutical Industry
in early
phases
and experience of applying those into drug development projects.
cGxP
awareness and experience applying this within an R&D environment.
Will have
Ideally has
experience with statistical procedures and software, particularly DoE and multivariate analysis.
Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here:
https://careers.jazzpharma.com/benefits.html .