Job Title: Vice President, Clinical Affairs
Job Type: Permanent
About the Role
We are seeking a seasoned and strategically minded Vice President of Clinical Affairs to lead the global clinical development function for an innovative Class III cardiovascular medical device portfolio. This is a critical executive role, operating at both board and operational levels, responsible for shaping clinical strategy, advising senior leadership, and ensuring the successful design and execution of complex clinical programs—from first-in-human through pivotal trials.
This position requires a highly experienced clinical leader who can confidently navigate the nuances of early feasibility studies, first-in-human trials, and pivotal study design, particularly within cardiovascular and implantable device environments.
Key Responsibilities
* Define and lead global clinical strategy aligned with regulatory and commercial objectives
* Act as a trusted advisor to the Board and Executive Leadership Team on clinical development pathways, risk, and opportunity
* Design innovative and efficient clinical development plans, including feasibility, first-in-human, and pivotal trials
* Assess and advise on optimal geographies for early-stage trials (e.g., Netherlands, Australia), including regulatory, ethical, and operational considerations
* Evaluate opportunities to streamline development timelines, including combining or sequencing early-phase studies where appropriate
* Provide expert guidance on study design, endpoints, patient selection, and statistical methodologies for Class III cardiovascular devices
* Oversee clinical trial execution, ensuring quality, compliance, and timely delivery
* Collaborate closely with Regulatory Affairs to align clinical evidence generation with MDR, FDA, and global requirements
* Engage with investigators, key opinion leaders (KOLs), and clinical partners to build strong study networks
* Lead interactions with regulatory bodies and ethics committees as needed
* Build and lead a high-performing clinical affairs team and external partnerships (CROs, consultants)
* Oversee clinical budgets, timelines, and resource allocation
Required Experience & Qualifications
* Extensive experience in Clinical Affairs within the medical device industry, with a focus on Class III cardiovascular or implantable devices
* Proven track record designing and executing first-in-human, early feasibility, and pivotal clinical trials
* Deep understanding of global clinical and regulatory frameworks, including EU MDR and US FDA requirements
* Demonstrated experience advising executive leadership and Boards on clinical strategy and development pathways
* Strong expertise in trial design, including adaptive designs and efficient study sequencing
* Experience working with international trial sites, particularly in Europe and Australia
* Ability to critically assess and optimise clinical development order, timelines, and evidence generation strategies
* Strong leadership, communication, and stakeholder management skills
* Experience in start-up or scale-up environments
* Familiarity with combining early-phase studies or innovative trial methodologies
* Strong network of cardiovascular investigators and clinical experts
* Advanced degree (MD, PhD, or equivalent) in a relevant discipline
What We Offer
* Competitive executive compensation and benefits package
* Opportunity to lead clinical strategy for groundbreaking cardiovascular technologies
* Direct influence at Board level and across global development strategy
* Hybrid working model with London office presence (2 days per week)
If you are a visionary clinical leader with deep expertise in cardiovascular medical devices and a passion for bringing transformative therapies to patients efficiently and safely, we would love to hear from you.
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