Full-time: 35 hours per week (we are open to considering flexible working patterns)
Fixed-term: until 31st May 2027
The Opportunity:
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shape and function in health and disease. In this project, we are interested to investigate changes to gene regulatory landscapes across development as facial progenitor cells differentiate into skeletal cell-types. You will utilisein vitromodels of facial development and leverage a combination of cutting-edge epigenomic methods, genome editing and synthetic biology approaches to gain fundamental insights into mechanisms of gene regulation, and human disease biology.
Your skills and attributes for success:
* Interest in mechanisms of gene regulation and enhancer biology in development and disease.
* Experience in generating and analysing epigenomic and transcriptomic datasets (e.g. ChIP-seq, ATAC-seq, CUT&RUN, 3C-based methods, RNA-seq etc), cell culture,in vitrodifferentiation methods and genetic engineering (preferable but not essential).
* Ph.D. (or near completion) in a relevant science subject.
* Proven track record of publication in peer-reviewed journals.
* Strong communication and collaboration skills.
£40,497 to £48,149 per annum (Grade 7)
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