Overview
We are seeking a passionate Scientist to join our Cell Therapy Biotechnology team. Your expertise in tumour immunology, immune cell biology, or cellular therapies will drive advances in oncology by developing and analysing advanced in vitro cellular systems. This is a fixed-term maternity cover position, focusing on optimizing CAR‑T cell function through genome editing (e.g. CRISPR) and employing advanced cell models and immune assays. You will have a central role in refining our mid‑throughput validation platform, using cutting‑edge cell engineering, automation, and physiologically relevant models to assess immunotherapy efficacy. The role offers extensive collaboration across our global organization and with leading external partners. You will support scientific excellence by presenting your work to internal stakeholders, conferences, and peer‑reviewed journals. As part of AstraZeneca's Cell Therapy Unit, you will join a vibrant scientific community dedicated to transformative drug discovery. We seek candidates with a solid background in cancer cell therapy and a genuine passion for scientific innovation. At AstraZeneca, your contributions are valued and rewarded in an ambitious, collaborative environment dedicated to making a meaningful difference for patients.
Qualifications
* Bsc in Immunology, Immuno‑oncology, or equivalent relevant experience.
* Practical understanding of cell therapy discovery and development, with knowledge of immunity and cancer biology—especially in solid tumours.
* Hands‑on experience with primary immune cells, cell enrichment, coculture assays, and viral delivery methods.
* Experience of complex immunoassays (e.g. multiparametric flow cytometry and imaging technologies).
* Experience in gene editing/silencing methods.
* Excellent communication and teamwork, with experience collaborating across disciplines and engaging both internal and external partners.
* Strong problem‑solving skills, with adaptability in fast‑paced environments.
* Track record of collaboration with academic and industry partners.
Desired Criteria
* Demonstrated record of scientific excellence through publications.
* Experience with 3D models (e.g. organoids), high‑content imaging, and automation.
* Skilled in cellular, DNA, and protein‑based assays, NGS, and metabolic analyses.
* Understanding of target discovery, drug screening, and in vitro/in vivo validation.
AstraZeneca's Commitment to Oncology Cell Therapy
AstraZeneca is a leader in Oncology with a global footprint and a proven track record of delivering best‑in‑class medicines. We are significantly investing in next‑generation cellular therapies for cancer, leveraging cutting‑edge expertise in biopharmaceuticals, advanced genome engineering, and immunology across both solid tumours and haematologic malignancies. This uniquely positions us to advance innovative cell therapy platforms and establish a high‑impact pipeline, At AstraZeneca, we believe even small opportunities can lead to big change. We value diverse thinking and support each other in creating innovative solutions. You will find support to grow your career and connect with others who share your passion for making a difference. Together, we are crafting the future of healthcare‑join us and help us set new standards for what a biopharmaceutical company can achieve.
At AstraZeneca, we transform bold ideas into life‑changing medicines. Joining us means being ambitious, results‑driven, and committed to making the impossible a reality‑together.
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