Role Location: Cambridge, UK
Role
As a Molecular Biologist in the GEO Team, you will contribute to the design and construction of large-scale synthetic gene loci that underpin our next‑generation discovery platforms. Using advanced genome engineering approaches, you will help create highly diverse systems for therapeutic antibody discovery, including bispecifics and VHHs. The role blends thoughtful genetic design with hands‑on experimental work to build the scientific capabilities that help our partners develop new medicines.
How You’ll Drive Impact
* Complex Locus Engineering: Design and implement complex humanization strategies using state‑of‑the‑art technologies to model human immune repertoire across diverse research platforms
* Quality Control: Apply rigorous scientific judgment to ensure consistency and reliability by critically evaluating data, experimental approaches, and conclusions
* Innovation: Approach scientific challenges with curiosity and an open mindset, contributing new ideas and methods while encouraging collaborative problem‑solving
* Execution: Take initiative and proactively move work forward, demonstrating ownership and accountability while contributing to team success
* Collaboration & Trust: Build strong working relationships by consistently delivering high‑quality work, acting with integrity, and supporting shared team goals
Why We Value You
* You hold a PhD Degree in Developmental Biology, Functional Genetics, Molecular Biology, Immunology, Cell Biology, or equivalent industrial experience
* You possess good knowledge of genetics and innovative techniques in generating transgenic animals
* You are familiar with genetic engineering: design of targeting and screening strategy, vector construction and preparation, data analysis and troubleshooting
* Precision Genome Engineering: You are proficient in CRISPR/Cas9 and advanced integration tools, such as Recombinase‑Mediated Cassette Exchange (RMCE) or site‑specific integrases (e.g., Bxb1)
* Comparative Immunogenetics: You possess a good understanding of repertoire generation mechanisms across different species, including V(D)J recombination and alternative diversification strategies such as gene conversion or somatic hypermutation
* Model Characterization: You have experience with the functional validation of new in vivo models, including flow cytometry, cell sorting, and the assessment of serum titers/binder affinity
* You will have a foundational knowledge of animal physiology, husbandry and welfare
* You have a working knowledge and a demonstrated ability to quickly learn and adapt to various software programs (e.g., Geneious Prime, Benchling, FlowJo)
* Accountability & Drive: You thrive in a nimble, startup‑style environment, owning projects from the initial "dry lab" design to the final "wet lab" validation
* You apply meticulous attention to detail in scientific thinking and documented writing to ensure accuracy, communicating and presenting information with clarity and precision
* You cultivate a proactive approach, demonstrating a strong eagerness to learn and support the team in achieving success
* You demonstrate an independent sense of urgency and are adept at driving projects forward through persistence and a commitment to integrity
Compensation & Benefits
* Competitive base and equity compensation commensurate with level of experience and independence
* 25 annual leave days (with one additional day every 3 years completed, up to 27 days)
* Annual stipend for continuing education with commitment to your career through an individualized professional development plan
* Comprehensive benefit package, including private medical insurance, pension contribution matching, mental health and well‑being support, and more
* Wellness and extensive employee assistance program (EAP) including resources for mental wellness
Diversity, Equity, and Inclusion
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com. We will make every effort to respond to your request for disability assistance as soon as possible.
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