About the role At TRI, our mission is to make Risk-Based Quality Management (RBQM) simple, making it accessible, understandable, and actionable for clinical trials of any scale and complexity. We develop innovative technologies and simplified solutions to empower research organisations and sponsors, ensuring the highest standards of trial integrity and participant safety. We are seeking an accomplished Head of PMO to lead TRI’s Value Creation Plan (VCP) projects, drive delivery excellence across the Senior Leadership Team (SLT), and own the design and rollout of TRI’s future Target Operating Model (TOM) covering systems, processes, decision making frameworks, team structures, handoffs, and how the organisation works end to end. This role demands someone who is equally strong in: Execution (getting projects delivered), Governance (bringing clarity and discipline), and Strategy & Design (operating model thinking, organisational optimisation). It is a senior, influential role that helps shape how TRI scales. Key Responsibilities Enterprise PMO & Value Creation Plan (VCP) Delivery Own and operate the enterprise-wide PMO, overseeing all strategic and cross‑functional initiatives. Lead the full lifecycle delivery of the Value Creation Plan (VCP). Establish clear prioritisation, sequencing, and dependency management across initiatives. Oversee initiative budgets, benefits tracking, and ROI realisation. Define and track outcome-based KPIs for all strategic programmes. Implement a disciplined operating rhythm for planning, reviews, escalation, and decision-making forums. Produce concise, decision-ready reporting for the SLT, Executive Chair, CEO, and Board. Actively manage risks, issues, and trade-offs, ensuring timely escalation and resolution. Chief of Staff – Executive Chair & CEO Drive follow-through and execution of Board and Executive actions. Coordinate and quality‑control Board packs, strategic papers, and executive updates. Ensure clarity of decisions, actions, ownership, and timelines across the Executive agenda. Support the Executive Chair and CEO in preparing for strategic meetings, off-sites, and reviews. Act as the central coordination point across the SLT on strategic priorities. Provide structured analysis, synthesis, and insight on key topics. Maintain a strong focus on execution and delivery, not diary management. Transformation Programme Leadership Serve as programme owner for major enterprise-wide transformation initiatives. Design and lead high‑priority transformation programmes in partnership with the CEO and Board. Apply structured methodologies (e.g., Lean, Six Sigma, process redesign, change management) to drive efficient delivery. Work hands-on with functional leaders to remove barriers, accelerate progress, and embed long‑term change. Lead the initial transformation of the Target Operating Model (TOM), including: Operating cadence and governance Clear accountabilities and decision rights Scalable, efficient end-to-end processes Transition to enforcing and operating within the TOM once implemented. Success in the First 12 Months Looks Like A fully operational PMO environment with governance, cadences, reporting, and clarity. SLT aligned, accountable, and consistently delivering against priorities. A complete review of TRI’s “ asis ” operating model with gaps, issues, and opportunities clearly defined. A signed off Target Operating Model with a clear roadmap. Execution of the first wave of TOM improvements, with measurable uplift (e.g., reduced cycle time, fewer handoff failures, better clarity/ownership). TRI is functioning with greater operational predictability, speed, and alignment. Your skills & qualifications Experience Significant experience in senior PMO, transformation, strategy execution, or operational leadership roles. Proven success delivering complex, cross-functional initiatives in scaling, SaaS, technology-enabled, or PE-backed environments. Strong financial and commercial acumen, including managing budgets and benefits realisation. Deep experience in programme governance, prioritisation, and disciplined delivery. Exposure to transformation programmes, TOM redesigns, and structured improvement methodologies (Lean, Six Sigma, etc.). Comfortable working with Board-level stakeholders and investor expectations. Skills Exceptional communication and facilitation. Lean Six Sigma methodology Ability to bring order, clarity, and structure into ambiguity. Strong analytical and process mapping capability. Experienced in a variety of tools for PMO (Jira/Asana /Power BI/Notion, etc.). Change management, influencing, storytelling. Benefits & compensation Salary up to £75,000 Flexible, remote-first working. You will be able to enjoy all the benefits of working from home, with access to coworking spaces close to you if required (via Hubble membership). Generous holiday as standard. We offer 27 days' holiday, with a company shutdown between Christmas and New Year. Sometimes we also offer an extra, discretionary, paid day off to celebrate a specific company success. Extra holiday on top. For every full year you are with TRI, you will earn an extra day of holiday, up to a maximum of 30 days. Carefully considered, market-leading salaries. We regularly benchmark our salaries to make sure we are offering at the top end of the scale. You will have your salary reviewed annually. Enhanced pension offer. Following your probation period, you can opt in to our enhanced pension contributions arrangement. It’s a salary sacrifice scheme, paid on your full salary (not just the ‘qualifying amount’), which means you get better pension contributions alongside valuable tax and National Insurance savings. Health and well-being support. We offer all employees a health cash plan with Simply Health, allowing you to look after your health and wellbeing every day. Our Optimise Level 5 plan includes cash back for a huge range of health services, including dental and optical, Virtual GP, face-to-face counselling and more. Life cover. You will be covered at four times your salary from day one, paid as a tax-free lump sum to your named beneficiary. In-person meetings and socials. We have company conferences each year, plus regular team meet-ups throughout the year. Training and development. We make sure that you are able to reach your full potential with TRI by offering you access to training and development, plus regular reviews and goal-setting with your line manager. About us At TRI, our mission is to make Risk-Based Quality Management simple; making it accessible, understandable, and actionable for clinical trials of any scale and complexity. We develop innovative technologies and simplified solutions to empower research organizations and sponsors, ensuring the highest standards of trial integrity and participant safety. Our History! 2013 Establishing our foundation in Cambridge, UK TRI marked its entry into the world of clinical trial quality management by opening our first office in the historic and intellectually vibrant city of Cambridge. This milestone symbolized our commitment to innovation and excellence, setting the stage for a future where research and technology converge to redefine industry standards. 2016 Introducing OPRA, a new era of monitoring Our journey took a significant leap forward in 2016 with the launch of OPRA-CM, our centralized monitoring platform. Designed with precision and user experience in mind, OPRA-CM revolutionized how research data is monitored, ensuring higher quality, efficiency, and compliance in clinical trials. This innovation underscored our dedication to transforming research methodologies through smart technology. 2020 Further advancing risk management In 2020, TRI once again pushed the boundaries of quality management by unveiling our advanced risk assessment and management tool, OPRA-RAM. This tool was developed to empower researchers to proactively identify, evaluate, and mitigate risks in their studies, ensuring the utmost integrity and reliability of research outcomes. This launch not only highlighted our ongoing commitment to safety and excellence but also set new benchmarks in research risk management.