We are seeking
to appoint a Research Assistant in Brain Tumour Biology to join Dr Pathania’s Laboratory at Ludwig Institute for Cancer Research, part of Nuffield Department of Medicine. Reporting to Manav Pathania, you will be a new core member of the newly relocated group in Oxford. You will assist postdoctoral research scientists and PhD students in utilising in vivo brain tumour models to identify molecular targets underlying tumour maintenance and resistance to chemo, radio and immuno-therapy, using genetic barcoding and clonal lineage tracing and single-cell and spatial omics. Some work developing in vivo CRISPR screening approaches will also be required. Training in all aspects of this work will be provided but some prior experience in cancer or neuroscience research involving mouse models is essential. Over the course of the project, you will be expected to develop substantial familiarity with using mouse models in cancer research and associated in vitro and in vivo techniques for describing and testing observations and making mechanistic insights. You will also assist the PI in lab personnel management, administration of finances, maintaining animal licence ethical approvals, grants, and manuscript preparation. A propensity for self-reliance and an ability to successfully troubleshoot roadblocks normally encountered over the course of carrying out frontier research is desirable. It is essential that you hold a degree in cancer biology, neurobiology, cell and molecular biology or a related field. You will have demonstrable experience in brain/cancer research using in vivo models, primary cell lines and PDX models. Equally, you will have prior experience in single-cell and spatial omics and in vivo functional genomics (CRISP, shRNA). Strong skills in decision-making, problem-solving, planning and organising analysis and research, with attention to detail are also required. You will have excellent communication skills, including the ability to write scientific text well, present data clearly, and communicate science effectively.