About Iso
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.
About the Medicinal Drug Design Team
We have an established, dynamic team of ~25 Medicinal Chemists in London, who are fundamentally redefining how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs Drug Design Engine - we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios.
Your Impact
We are seeking an experienced and strategic Head of Medicinal Chemistry to join our Drug Design team. This is a pivotal role for a motivated scientific leader who is eager to shape the future of drug discovery at the intersection of medicinal chemistry and artificial intelligence. You will provide scientific leadership and strategic direction for the Medicinal Chemistry team, responsible for delivery and guidance of projects to clinical candidate nomination.
What you will do
* Utilise your deep track record of modern drug design to oversee and deliver the London Drug Design portfolio, providing technical portfolio guidance.
* Provide direct line management and strategic oversight for a growing team of ~25 Medicinal Chemists.
* Champion an AI-First Approach, actively ensuring that every chemist in the organisation is empowered and supported in the application of AI tools.
* Collaborate both internally and with third-party organisations, to build highly effective and efficient connectivity between Chemistry, Computational Drug Design, Biology, and Pre-Clinical Development teams.
* Represent the company externally, interacting with existing and prospective collaborators.
* Constantly look for ways to do drug discovery differently, optimising workflows and challenging traditional medicinal chemistry dogmas.
Skills and qualifications
Essential:
* PhD in Synthetic Organic Chemistry, Medicinal Chemistry or a related technical field, or equivalent industrial experience.
* Solid foundation in medicinal chemistry with a minimum of 10+ years previous industrial experience within a pharma/biotech/CRO setting.
* Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression.
* A genuine passion for drug discovery and a visible desire to move away from "business as usual," coupled with enthusiasm for the potential of AI/ML.
* Demonstrated experience in line management, mentorship, and developing scientific talent.
* Experience of working with and closely managing CRO resource.
Nice to have:
* Experience of successful application of fragment-based drug design approaches.
* Experience of structure-based drug design.
* Proven track record of leading large teams and managing through other managers.
Hybrid working
It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in).
We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.
#J-18808-Ljbffr