Job Description
Principal Scientist/Director provides strategic development and implementation of cutting‑edge mathematical and economic models to enhance understanding of diseases, quantify outcomes, and communicate the value of our company products to patients, providers, payers, and policymakers. This role offers strategic and technical leadership, utilizing model‑based scientific and business insights across all phases of drug and vaccine development. Additionally, the scientist serves as the Health Economic and Decision Sciences (HEDS) lead for one or more value evidence teams. These teams are responsible for generating evidence, including the development of health economic, disease, and other mathematical models to enable business and scientific insights for vaccines aimed at preventing infectious diseases.
Position Qualifications
Education Minimum Requirement
* Masters in a quantitatively oriented discipline such as health economics, mathematical epidemiology, applied mathematics, operations research, public health, and statistics
* PhD (preferred)
Required Experience and Skills
* Experience in the design and development of health economic modeling approaches to enable internal and external decisions
* Experience in the design and analysis of mathematical models of infectious diseases and vaccination
* Experience managing research teams
* Excellent organizational and communication skills (oral and written)
* Ability to work independently and effectively interact with a broad group of stakeholders
* Ability to balance multiple priorities, meet deadlines, and work under pressure
* Strong record of research publications in peer‑reviewed journals
Preferred Experience and Skills
* Advanced knowledge of economic evaluation and cost‑effectiveness analysis.
* Extensive experience in scientific computing and programming with software such as Mathematica, MATLAB, Python, or C++.
Required Skills
Ability to Work Under Pressure, Bioethics, Biostatistics, Data Management, Economic Evaluations, Health Economics, Health Outcomes Research, Infectious Disease, MATLAB, Operations Research, Pressure Management, Project Reviews, Python (Programming Language), Researching, Scientific Research, Social Collaboration, Stakeholder Relationship Management, Strategic Planning, Technical Leadership
Preferred Skills
Current Employees apply HERE
Current Contingent Workers apply HERE
Eligibility and Application
US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. If you need accommodation during the application or hiring process, please click here.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics. For more information about your rights under U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
Learn more about your rights, including under California, Colorado and other US State Acts.
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid schedule consisting of three total days on‑site per week, Monday‑Thursday, although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business‑critical tasks require an on‑site presence. This hybrid work model does not apply to field‑based positions, facility‑based, manufacturing‑based, or research‑based positions where the work to be performed is located at a Company site; positions covered by a collective‑bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this hybrid work model guidance also does not apply to roles that have been designated as “remote”.
The salary range for this role is $187,000.00 - $294,400.00.
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for an annual bonus and long‑term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
Location Restrictions
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.
Search Firm Representatives
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre‑existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation: Domestic
VISA Sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Hybrid
Shift: Not Indicated
Valid Driving License: No
Hazardous Material(s): n/a
Job Posting End Date: 12/8/2025
*A job posting is effective until 11:59:59 PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID: R367204
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