About the role:
We are seeking a motivated and talented Computational Biologist to join the Bioinformatics and Biostatistics (BBS) Team within the CRUK National Biomarker Centre (NBC). The primary focus will be on analyzing single-cell, spatial transcriptomics, and proteomics data. NBC's mission is to develop, validate, and implement biomarkers to optimize cancer patient treatment. Renowned for research into minimally invasive biomarkers, or liquid biopsies, NBC integrates clinical, molecular, and computational sciences to enhance cancer care through advanced data analysis.
In this role, you will collaborate with clinicians, biologists, bioinformaticians, and computational scientists to analyze various molecular datasets from patient samples and models, focusing on lung cancer biology aspects like metastasis, tumour plasticity, and immunology. You may also develop bioinformatics methods to support these investigations, working with large datasets including genomic, epigenomic, transcriptomic, immunogenomic, and imaging data from blood, xenografts, and tissue samples. Access to state-of-the-art facilities and high-performance computing resources at NBC and the CRUK Manchester Institute will support your work.
About you:
You should possess a postgraduate degree in Bioinformatics/Computational Biology or a related field (or equivalent experience), with some experience in single-cell bioinformatics or a strong desire to learn. Alternatively, an undergraduate degree in these areas with significant relevant research experience is acceptable.
You should be familiar with bioinformatics tools for analyzing bulk and single-cell transcriptomic data, capable of coding in R for reproducible analysis, and have a solid understanding of molecular biology. Experience with other molecular data types (epigenomics, genomics, proteomics), NGS data processing, and familiarity with Linux command line are desirable. Knowledge of cancer biology, biomarker development, and machine learning approaches for high-throughput data analysis is also beneficial.
You should have excellent communication skills and the ability to work effectively with interdisciplinary teams. Experience in multidisciplinary teamwork is advantageous.
Additional information:
Visit our website for more about the Bioinformatics & Biostatistics Research Group. The NBC is a leading translational research centre within The University of Manchester, aligned with the Cancer Research UK Manchester Institute, and is housed in the state-of-the-art Paterson Building, attached to The Christie NHS Foundation Trust, one of Europe's largest cancer treatment centres. This environment offers excellent opportunities for basic, translational, and clinical research.
Application process:
Please see the link to apply for the role on the CRUK website. After the closing date, this job description will be removed from our website. Save a copy if you wish to refer to it later.
Disabilities and support:
The University of Manchester is committed to supporting disabled applicants and will make reasonable adjustments during recruitment and employment. Contact the HR Department for support or alternative formats.
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