Senior - Principal Scientist
A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies.
Role Summary
The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development.
Key Responsibilities
* Lead in vitro and in vivo validation of TCR-based T cell engagers.
* Design and characterize TCRs targeting proprietary and partnered disease indications.
* Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs.
* Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing.
* Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation.
* Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs).
Required Qualifications
* PhD in Immunology, Cell Biology, Biochemistry, or related discipline, with:
* 2-3 years of industry experience.
* Demonstrated experience with in vitro and in vivo validation of T cell engagers, ideally through to IND-enabling studies.
* Solid understanding of molecular biology techniques (e.g., cloning, PCR).
* Hands-on experience with protein expression, purification, and biophysical characterization.
* Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable.
* Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus.
* Prior SOP development and documentation experience is advantageous.