Salary: Research Assistant: £33,002 - £34,610 per annum Research Associate: £35,608 - £46,049 per annum Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. Closing Date: 24 September 2025 The Role This role offers an exciting opportunity for a structural biologist to apply their skills to drug discovery through generation and analysis of protein X-ray crystallography and biophysical characterisation of test compounds. The role will also provide the opportunity to learn and develop skills in structure-based drug design. The role is ideal for someone who has, or is about to be awarded, a PhD in structural biology and would like to gain experience of drug discovery. It would provide excellent experience for a future career in academic or industrial drug discovery research. Based in the Structural Biology Section of the Newcastle University Centre for Cancer Drug Discovery Unit, working with Prof. Martin Noble and Dr. Mat Martin, you will join a vibrant multidisciplinary group of chemists, bioscientists and structural biologists working at the forefront of anti-cancer drug discovery with an excellent track record of successfully bringing new cancer medicines to market. The focus of the project is the optimisation of compounds that inhibit a critical protein target that will lead to drugs for currently untreated cancer types. It employs cutting-edge structure based drug design and property-based optimisation approaches to optimise compounds to drug candidates. The Newcastle Drug Discovery Unit is a founder member of Cancer Research Horizons – Therapeutic Innovation (CRH-TI), CRUK’s exciting new vehicle dedicated to translating basic research into patient benefit. To learn more about CRH-TI, click here, and to learn more about our approach to small molecule drug discovery in Newcastle, click here As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level. We are committed to building and maintaining a fair and inclusive working environment. The role is a full-time, fixed term (12 month) position in the first instance. Candidates who are about to be awarded their PhD are encouraged to apply. The start date will ideally be October 2025, but some flexibility is possible. Informal enquiries can be made to Martin Noble Martin.Noble@ncl.ac.uk or Dr. Mat Martin Mathew.Martin@ncl.ac.uk Applications should be made through the Newcastle University jobs portal: https://jobs.ncl.ac.uk, where you are invited to provide evidence of how you meet the essential criteria required for the role outlined in ‘The Person’ by uploading a letter of application along with your Curriculum Vitae (CV) Key Accountabilities Generation of structure of protein-ligand complexes to support the drug discovery project Biophysical characterisation of test compounds Contributions to new compound design Regular liaison with the Principal Investigators to organise workload and the provision of support for the satisfactory operation of research activities, facilities and equipment Training and mentoring of students on specific experimental techniques and in the use of specialised laboratory equipment Communication of results both orally, informal presentation and written documents Excellent laboratory record keeping of all experimental procedures and outcomes, enabling interpretation by other team members Risk assessments and maintenance of safety laboratory records (e.g. COSHH and other regulations) in consultation with academic staff Be responsible for the care and cleanliness of laboratories To participate in and contribute to the development of a vibrant research culture The Person Knowledge, Skills and Experience (Essential) Expert experience in structural biology and biophysical techniques especially X-ray crystallography, surface plasmon resonance and protein mass spectrometry Experience of managing safety aspects of work (e.g. COSHH) Excellent communication skills, both oral and written, with the ability to present to internal and external stakeholders Excellent organisation and planning (Desirable) Experience of drug discovery A track record of successful, high quality, publications Experience of laboratory supervision of students (PhD, MSc, BSc) Familiarity with database software Attributes and Behaviour Ability to work independently and as part of a team Enthusiastic, with a strong work ethic A demonstrated commitment to ensuring our institutional strategy for Equality, Diversity & Inclusion (EDI) is embedded in all our research group activities, with a commitment to ensuring dignity and respect in the workplace to the highest standard Qualifications A PhD awarded in the area of structural biology or similar subject (required to be appointed at Research Associate level only) - applicants who are about to receive their PhD are also particularly welcomed (to be appointed at Assistant Level) An undergraduate degree (or equivalent) in a relevant science subject Newcastle University is a global University where everyone is treated with dignity and respect. As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution. We are committed to being a fully inclusive university which actively recruits, supports and retains colleagues from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all of our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from individuals who can complement our existing teams, we believe that success is built on having teams whose backgrounds and experiences reflect the diversity of our university and student population. At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality. We also hold a Race Equality Charter Bronze award in recognition of our work towards tackling race inequality in higher education REC. We are a Disability Confident employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme. In addition, we are a member of the Euraxess initiative supporting researchers in Europe. Requisition ID: 28529