Overview
Job Title: Principal Scientist - Protein
Rate: £23.89 per hour
Start Date: 19th January 2026
We are seeking a Principal Scientist to direct and inform our process development and discovery. The ideal candidate will have a deep understanding of protein expression systems and how to optimise conditions to improve protein quality. They will also require a good knowledge of protein purification methods to leverage the optimisation in expression conditions to maximise final protein quality. This two-year contract offers the opportunity for the successful candidate to join a dynamic team that works across multidisciplinary functions in a leading AgriTech business.
Responsibilities
* Provide scientific leadership and technical guidance to team members and project teams.
* Be the technical lead to translate expression optimisation from shake flask to bioreactor.
* Design and refine expression methods and protocols to optimize protein quality.
* Investigate the relationship between expression conditions and protein quality attributes across key projects.
* Collaborate with team members and across functions to enhance overall process improvements.
* Drive optimisations in upstream processes with a data led approach.
* Work safely and with due care to others ensuring compliance with company HSE policies.
Qualifications
* Post Doc or equivalent experience in Biotechnology, Microbiology or other similar disciplines.
* 8+ years of hands-on experience in upstream bioprocessing with expertise in:
* Recombinant protein expression (bacterial, insect, yeast or plant systems).
* Knowledge and experience of working with bioreactors.
* Experience and knowledge of transferring shake flask processes into bioreactors.
* Good knowledge of protein purification methods and techniques.
* Strong evidence of troubleshooting and innovative problem solving.
* Strong understanding of how upstream decisions impact downstream processing outcomes.
* Excellent communication skills with the ability to present complex concepts clearly.
* Knowledge of how construct design can impact protein expression.
* Knowledge and application of AI tools and models to inform experimental design.
* Knowledge of DoE approaches for method optimisation.
* Experience with Ambr250 micro bioreactor systems.
* Background in protein characterisation to validate protein quality from a bioprocess.
* Experience of working with scalable bioprocess technologies e.g. Tangential flow filtration.
* Industry experience in Biopharma, AgriTech or related sectors.
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