Overview
This is an exciting opportunity to join the Respiratory, Immunology and Inflammation Biology and Translational Units (RIIBU/TU), which oversee preclinical and early clinical assets across several disease areas including lung, liver, kidney, and rheumatology. The Units consist of multiple disease-aligned groups including Inflammation and Fibrosis, Hepatology, Renal and Respiratory and Translational Sciences. This role will be within the Analytics or Translational team.
Role 1
Role 1 details: Key Placement Learnings
* Combining biological knowledge and analytic skills to maximise impact in progressing new medicine opportunities.
* Coding in R.
* Implementing bioinformatic analysis workflows to deliver foundational and project-aligned RNA-sequencing data and may include single cell and spatial transcriptomics data.
* Developing intricate data-dashboards for lab assay outputs to make results interactive and impactful for our biology experts.
* Training others in analytics and elevating the digital fluency of the department.
* Close collaboration with our business partners in Human Genetics and Genomics, AIML, Data and Predictive Sciences, and Research Statistics.
Role 2 - Human Biology and Omics Technologies
Workplace Arrangements: Full time on site required
Overview of the Department Roles within the Human Biology and Omics Technologies department comprise of several disciplines that provide scientific knowledge required to develop translational models and assays to enable the discovery and validation of novel therapeutic targets, through gaining a deeper understanding of causal biology and mechanisms. The role will involve advanced cell culture, genome editing, high content imaging, automation, functional assays, flow cytometry, ELISAs and omics.
* Development of advanced humanised cellular models with microfluidics such as organ-on-a-chip platforms and organoids.
* Application of high-throughput genomic & transcriptomic approaches to enable the discovery and validation of potential new therapeutic targets.
* Genome editing in primary human cell models of diseases with multitude functional readouts for target identification and validation.
* Development of high content imaging and automation processes to support specialist imaging assays for various projects within Target Validation.
* Development of Human induced pluripotent stem cell (iPSC)-derived models and implementation of genome editing pipelines
Role 3: Discovery Biology, Screening and Chemical Biology
Workplace Arrangements - Flexible working via performance with choice (office & home working may be available)
Overview of the Department The primary responsibility of the Discovery Biology and Screening department is to deliver high quality, biologically relevant pre-clinical leads for all GSK therapeutic areas, by employing a combination of scientific tools and methodologies, including but not limited to assay development, high throughput screening, compound profiling, and mechanism of action studies.
* Individual project driven by student, generating data to contribute to program progression or the implementation of new technologies.
* Analyse data to determine the next experimental steps.
* Screening against safety liabilities for progression of multiple programs and reducing attrition.
* Regular journal clubs to learn how to analyse and write journal articles.
* Attend meetings and present progression and contributions.
* Cross department awareness days to learn about other parts of the business.
* Technologies include Fluorescence, Luminescence, Flow cytometry, Cell Imaging, Mass Spec
* Complex models
* Scientific communication (for example presentations and scientific writing)
* Planning and designing experiments
Role 4 - Genetic and Investigative Toxicology
Workplace Arrangements: Full time onsite required
Overview of the Department The department provides data in the areas of drug safety, bioimaging, biological markers and disposition to support the transition of therapeutic molecules from pre-clinical to the clinical stages of development. Genetic and Investigative Toxicology scientists provide expertise around safety and drug disposition to projects from the earliest biological target identification stage through to GSK medicines already on the market.
* Designing, planning, and conducting experiments to answer specific safety related objectives or hypotheses.
* Evaluating potential genotoxic liabilities aligned to ICH S2 (R1) (e.g., Mutations, DNA/chromosomal damage) from early-stage drug development through to post marketing), via literature reviews and establishment of expertise in one or more of the following technologies: bacterial and mammalian cell/tissue culture/analysis, flow cytometry, microscopy and image analysis.
* Running in vitro experiments and measuring toxicity using a range of multiparametric plate-reader assays, transcriptomics, DNA sequencing and evaluations of bioenergetics and mitochondrial function.
* In vitro cell culture - working with cell lines and primary cells.
* Critical assessment and interpretation of data.
* The importance of collecting and documenting experimental methods and results carefully.
* Writing up experiments in laboratory notebooks to aid current and future projects with decision making regarding the development of compounds.
Role 5 - Cellular Biomarkers Flow Cytometry
Workplace Arrangements: Flexible working via performance with choice (office & home working may be available)
Overview of the Department Cellular Biomarkers is responsible for the delivery of complex multi-parameter flow cytometry panels and the subsequent application of these panels to clinical trial sample analysis. The data generated by these biomarker panels helps us to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.
* Assist in the design, development, optimisation, and validation of new flow cytometry panels for immunophenotyping, cytokine production, rare cell identification, target engagement and/or receptor occupancy.
* Work with spectral flow cytometers within multiple disease areas spanning the entire GSK portfolio, as well as develop extensive wet lab and analytical skills.
* Plan, execute, and interpret scientific, present results and collaborate with other scientists within Platform Sciences.
Role 6 - Immunoassay - Soluble Biomarkers
Workplace Arrangements: Flexible working via performance with choice (office & home working may be available)
Overview of the Department The Soluble Biomarkers team is responsible for the identification and implementation of new precision medicine strategies, as well as the close monitoring of target engagement and surrogate biomarker endpoints to support clinical trials. The department delivers high-quality data to support both preclinical and clinical studies for NCEs and biopharmaceuticals, as well as developing analytical assays to measure drugs and soluble proteins.
* Immunoassay platforms such as Gyrolab, MSD, ELISA and Quanterix HD-X.
* Working across multiple disease areas, such as oncology, respiratory and immuno-inflammation
* Developing and validating methods for the measurement/characterization of soluble proteins in biological samples.
* Routine analysis of Pharmacodynamic markers in biological matrices to applicable standards using defined analytical methods
* Processing and evaluating data using appropriate software.
* Authoring reports summarising data generated during routine analysis.
Role 7 - Biopharm Analytical Scientist
Workplace Arrangements: Full time on site required
Overview of the Department This role is within Drug Substance and Product Analysis UK, which is committed to de-risking and speeding up GSK's portfolio of biopharmaceuticals from Discovery Research to Clinical Manufacture. The department uses cutting-edge analytical technology to screen candidate molecules for 'manufacturability' and quality before transferring to late-stage development and clinical manufacturing.
* Operating advanced automated equipment such as analytical instruments, multifunctional platforms, and liquid handlers.
* Organizing, conducting, and reporting on project work experiments.
* Producing high-quality results within set timelines and contributing to the evaluation and interpretation of experimental data.
* Teamwork and flexibility, making it an ideal opportunity for those eager to gain experience in a multi-disciplinary department.
* Regular interaction with other groups within GSK R&D at Stevenage and the USA.
* Playing a vital role in employing, optimising, and developing automated workflows to expedite drug development processes.
Role 8 - Modality Platform Technologies
Workplace Arrangements: Full time on site required
Overview of the Department The Modality Platform Technologies department is driven by its mission to develop innovative therapeutic approaches that address the most pressing challenges in medicine today. The department aims to unlock the potential of advanced modalities to improve patient outcomes. One of the department's key focus areas is targeted protein degradation, an emerging approach that seeks to address diseases that are difficult to treat with conventional methods. During this placement, you will gain exposure to a variety of laboratory techniques in protein degradation, protein-protein interaction and protein-ligand interaction studies, e.g. Western blotting, CRISPR gene editing, immunoprecipitation, FRET, BRET.
* Design, execute, and interpret experiments in targeted protein degradation and proximity-induced pharmacology
* Collaborate with cross-functional teams to deepen our understanding of protein degradation pathways and their therapeutic potential
* Employ state-of-the-art techniques and technologies to identify and validate novel targets
* Maintain detailed and accurate experimental records, analyse data, and present findings to the research team
* Contribute to drafting research publications
* Expand your expertise in biochemistry, molecular and cell biology, and chemical biology
Role 9 - Protein and Cell Sciences
Workplace Arrangements: Full time on site required
Overview of the Department Protein and Cell Sciences (PCS) uses advanced technologies to generate and validate protein and cell-based reagents in support of both small molecule and biopharmaceutical programs. Vectors are designed and produced using molecular biology techniques (gene cloning, DNA sequencing, PCR), and expression carried out using bacterial and mammalian cell culture systems (E.coli, HEK transient, CHO stable). Proteins are purified using appropriate chromatographic techniques in conjunction with programmable purification platforms (affinity, ion-exchange, size exclusion chromatography), and characterised using state-of-the-art analytical tools (mass spectroscopy, electrophoresis, reversed phase chromatography).
* Design and production of vectors using molecular biology techniques (gene cloning, DNA sequencing, PCR)
* Expression of proteins and antibodies using bacterial and mammalian cell culture systems
* Purification of proteins/antibodies using appropriate chromatographic techniques in conjunction with programmable purification platforms (affinity, ion-exchange, size exclusion chromatography)
* Characterisation of proteins/antibodies using state-of-the-art analytical tools (mass spectroscopy, electrophoresis, reversed phase chromatography)
* Development of automated methods for high throughput expression and purification of proteins/antibodies
* Analysis of data and recording of experiments
* Presentation of results at project and group meetings
Role 10 - Large Molecule Research
Workplace Arrangements: Full time on site required
Overview of the Department Together with their therapy area partners, GSK Large Molecule Research are discovering, developing, and manufacturing novel medicines to benefit patients around the globe. The department is building a state-of-the-art end to end Biopharmaceutical capability, which delivers efficient discovery of antibody molecules that are selected and engineered for rapid development.
* Develop scientific writing and presentation skills
* Gain experience in data analysis
* Build on existing understanding and interest of Molecular Biology; Cell Biology; Immunology or Protein Biochemistry.
Role 11 - Extracellular-Targeted Cancer Therapeutics
Workplace Arrangements: Flexible working via performance with choice (office & home working may be available)
Overview of the Department The Extracellular-Targeted Cancer Therapeutics (ETCT) Biology Unit is part of the GSK Oncology drug discovery pipeline. The department aims to develop effective cancer therapies targeted at cancer-specific biology. Their primary focus is on two antibody-based modalities: Bispecific T-cell engagers (TCEs), and Antibody-drug conjugates (ADCs).
* Cell culture, cell viability assays, flow cytometry, molecular biology and ELISAs.
* Develop scientific research and professional skills, e.g. experimental design, experimental record keeping, data analysis, reporting and presentation skills.
* Gain a deeper understanding of tumour biology, T-cell function, targeting modalities and the immuno-oncology landscape.
* Deliver a research project aligned with our department goals
* Perform experiments in our cell and molecular biology laboratory
* Learn data analysis methods and present experimental results within biology meetings and departmental meetings, with opportunities to present to a larger audience.
Role 12 - Biopharm Analytical Automation
Workplace Arrangements: Full time onsite required
Overview of the Department Analytical Platforms and Platform Modernisation (APPM) sits in the Analytical Development department of Pharma R&D. In our department, we focus on providing technologies for the business to facilitate and support the development of new medicines. Among these technologies, the Analytical Automation and Digital Platforms Team UK aims at implementing automated workflows to optimise the use of resources, accelerate drug development, and generate high quality, standardised data.
* Operating and scripting advanced automated equipment such as liquid handlers, multifunctional platforms, and analytical instruments.
* Employing, optimising, and developing automated workflows to expedite drug development processes.
* Close collaboration with scientists from various departments, offering exposure to a multidisciplinary environment.
* Comprehensive training in essential analytical techniques and processes.
* Playing a role in producing high-quality results within set timelines and contributing to the evaluation and interpretation of experimental data or new instruments
Role 13 - Bioimaging - Non-Clinical Histology
Workplace Arrangements: Full time on site required
Overview of the Department The NCH team supports non-clinical Research from early Discovery up to the point where the project enters the clinical trials for the first time. We use classical histology techniques, advanced molecular biology, and computer science to analyse tissue samples from pre-clinical animal models and Complex In Vitro Models (CIVMs). These methods enable us to deliver unique data to project teams to enable them to progress projects with confidence. Specifically, we deliver focused spatial biology transcript/protein measurements to address specific hypotheses addressing mechanisms of action of tool molecules or GSK drugs and/or spatial localisation of cells/cellular responses.
* To provide support for projects using the capabilities and technologies within the Spatial Multiplexing Team.
* Learn spatial transcriptomic and proteomics quality control of samples and full assay workflow.
* Project scoping and planning
* Building relationships with diverse matrix teams supporting project delivery
* Sectioning, RNA extraction, slide staining and image acquisition.
Role 14 - Bioimaging - Cellular Imaging and Dynamics
Workplace Arrangements: Full time on site required
Overview of the Department At GSK's Bioimaging department, formed in 2016, we are uniting the power of in-vivo and ex-vivo imaging to revolutionize our understanding of drug distribution and its impact on living biological systems. Our Cellular Imaging and Dynamics group is at the heart of this innovation, supporting all areas of Research and beyond, with a focus on bioimaging at cellular and ultrastructural resolutions. We are not just users of existing technologies-we are innovators, constantly staying ahead of the curve through our expansive internal and external networks. Ready to contribute to multiomics analysis at the single-cell level, exploring mass spectrometry-based proteomics at the cell and tissue level?
* Map the distribution of unlabelled drug-related materials and endogenous metabolites with precision at the cellular level, influencing the efficacy and safety of compounds.
* Provide critical mass spectrometry and fluorescent microscopy imaging data that drives the development of groundbreaking new medicines across a diverse range of therapeutic areas.
* Explore how compounds interact with cells and alter underlying biological processes.
* Hands-on training in mass spectrometry, learning to identify endogenous and exogenous molecules from individual cells.
* Sampling from live cells and performing both optical and mass spectrometry imaging at cellular and sub-cellular resolutions.
* Cell culture and live cell imaging.
Role 15 - Oncology Research Unit
Workplace Arrangements: Flexible working via performance with choice (office & home working may be available)
Overview of the department The Oncology Translational Research Organisation (OTRO) focuses on developing novel biomarkers to stratify patients for innovative individual or combination therapies. By integrating complex model systems, AI/ML technologies and reverse translation of clinical data, OTRO aims to identify new therapeutic targets, biomarkers, and test translational hypotheses. We support the Oncology Biology Units through development of exploratory predictive biomarkers for research assets and guidance on assay development to support Phase 1 trials. We employ 3D ex-vivo system cellular models, patient derived organoids (PDOs) of human cancers to study how tumour cells interact with immune cells based on treatment. In both PDOs and matched patient tissue samples, we apply multiomic analyses including spatial transcriptomics, multiplex immunofluorescence, exosomal protein/DNA analysis.
* Drive and be responsible for a project that contributes to ongoing work within the department.
* Gain a deeper understanding of immunology, tumour biology and how these are combined in immuno-oncology research.
* Design robust experiments to investigate project-specific questions about drug or disease biology.
* Learn and apply imaging methods such as multiplex immunofluorescence to answer scientific questions.
* Implement data and image analysis tools and software.
* Write detailed experiment reports including methods and findings.
* Present data and experimental findings to project teams.
General notes
Please read the degree requirements for each role carefully before applying. Other requirements include that you will have completed a minimum of 2 years of your undergraduate degree but will not have graduated at the start of your placement. You must be enrolled at a UK or ROI University for the duration of your placement. Language requirement: Written and spoken fluency in English. Additional skills required across roles include teamwork, communication, time management, problem-solving, networking, data analysis and management, and technical skills as detailed in each role description.
Benefits and Additional Information
We are 100% open to all talent and aim to recruit from the widest possible backgrounds. This includes inclusion at GSK. In addition, the programme offers a competitive salary, bonus opportunities, private healthcare, wellbeing resources, volunteering days, and networking opportunities through Employee Resource Groups and IPUnite.
Duration and Application
Duration: 1 year (approximately)
Salary: £25,400 plus a bonus.
Application Closing: Early applications are encouraged as candidates will be reviewed regularly, and the advert may close at any point.
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