Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building and Kavli Institute, Oxford, OX1 We are looking to hire an ourstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that has as its goals to understand the response of RNA polymerase to DNA damage-induced transcription stress. This post is fixed term for 3 years. What are you going to do? In this fully-funded project, you will:• employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress;• develop an interdisciplinary skillset by acquiring a practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies;• interact with biochemist and structural biology collaborators based at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer institute) in the context of collaborative projects;• come up with suggestions to expand the interdisciplinary skillset as necessary for the benefit of the project;• employ simulations and data analysis routines to analyze your data;
1. publish your results together with collaborators;
2. have the opportunity to obtain teaching experience and improve your leadership skills while guiding undergraduate and graduate students;
About the project Requirements For this innovative, interdisciplinary project, we are looking an excellent scientist with:• a successfully completed Ph.D. degree (or close to obtaining) in quantitative biochemistry or biophysics;• practical experience and scientific maturity in the above areas;• strong experimental and quantitative skills;• an interest in working in biophysics while interfacing with biochemist and structural biology collaborators (and developing a biochemistry skillset to enable this if not already present);• an independent, well-organized, and reliable work style together with an ability and interest in working in a small team;• good interpersonal communication skills and a strong interest in the broader fields of replication and transcription, thereby contributing to collaborative work and to our interactive lab culture;We look for friendly and driven colleagues to enrich our team. We would like to welcome our new colleague in the fall of 2025. Who are we? Information and application