Performance analysis to assess improvements to solubility/bioassessability using a range of techniques and exploring sample preparation to improve bio-enhancement outcomes. This position is based at our client site in Stevenage; travel to the Ware site may also be required.
Responsibilities:
1. Perform screening assessment of various bio-enhanced formulation options using techniques such as spray drying (SD), small-scale hot melt extrusion (HME), lipid-based formulations (LBFs), and size reduction via micronisation and cryo-milling.
2. Perform physical characterization using techniques like differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), microscopy (Optical and Hot Stage), X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), Raman spectroscopy, particle size analysis, rheology, and viscometry.
3. Conduct in vitro performance analysis using HPLC, mass spectrometry, UV-spectroscopy, dissolution testing, and artificial membrane permeability assays.
4. Complete the write-up of experimental results on electronic notebook systems, provide technical reports, and present findings and recommendations to project leads and supervisors.
5. Participate in lab meetings, raising safety and quality concerns, and engage in management and housekeeping audit activities.
Qualifications:
* B.S./M.S. degree in Analytical Science, Chemistry, Pharmacy, or equivalent industry experience, with 1-3 years of laboratory-based experience, primarily in the pharmaceutical industry.
* Experience working with data integrity expectations within a non-GxP environment.
* Knowledge and experience of bio-enhancement techniques to improve drug solubility.
* Knowledge and experience of in vitro characterization methods such as solubility and dissolution.
* Some knowledge of solid-state analytical methodologies like X-Ray powder diffraction and Raman spectroscopy.
Additional Information:
Our 4i Values: Integrity, Innovation, Intensity, Involvement. If you resonate with these values and want to contribute to delivering safe and effective therapeutics, submit your application.
Work Schedule: Standard (Monday-Friday)
Environmental Conditions: Adherence to GMP and safety standards.
About Thermo Fisher:
Thermo Fisher's clinical research business is a leading global contract research organization dedicated to serving science and improving health worldwide. Our Analytical Services team offers a functional service provider solution, providing onsite experience at pharmaceutical or biopharmaceutical companies while maintaining full benefits.
Purpose of the Role:
Perform bio-enhancement and pre-formulation characterization studies to support oral formulation development, including in vitro testing.
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