We are seeking
a Postdoctoral Research Scientist (Neuronal Cell Biology) to join the Wade-Martins Laboratory at the Kavli Institute of Nanoscience Discovery within DPAG. The ideal candidate will be a neuronal cell biologist with experience working in neuronal models of neurodegeneration, ideally in human stem cell-derived models, and a good knowledge of Parkinson’s disease. In this role, you will differentiate iPSC-dopamine neurons from Parkinson’s patients and controls to target the pathological protein alpha-synuclein. You will treat neurons with peptides targeting alpha-synuclein and use cellular assays to test for alleviation of protein pathology and disease phenotypes. This post is available immediately until 31 August 2027. Key responsibilities: • Undertake analysis of the phenotypic effect of treating neurons with peptides targeting alpha-synuclein on cell biology phenotypes in cellular models of Parkinson’s • Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines • Contribute ideas for new research projects • Develop ideas for generating research income, and present detailed research proposals to senior researchers • Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters Selection criteria: • Hold, or be close to completion of, a PhD/DPhil in molecular and cellular neuroscience, or equivalent • Knowledge of the cell and molecular biology mechanisms of Parkinson’s disease, or related neurodegenerative condition • Experience in neuronal cell culture, preferably in human pluripotent stem cells • Experience in setting up cellular assays, and techniques in cell and molecular neuroscience What we offer: Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle and electric car loan schemes • Employee Assistance Programme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans While this is a full-time role, we welcome applications from individuals who wish to be considered for flexible working arrangements.