We are seeking
a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration within the Department of Physiology, Anatomy and Genetics at the University of Oxford. The ideal candidate will be a motivated and skilled cell biologist with experience in stem cell culture, neuronal differentiation, and phenotypic assays. A strong background in neurobiology, cell imaging, and molecular techniques, along with excellent organizational and collaborative skills, is essential. Key responsibilities:
1. Perform cellular, molecular and metabolomic assay techniques in iPSC-derived neurons from patients to test novel modulators of lysosome function
2. Understand the mechanism of action of novel modulators of lysosome function across cell and organelle biology in iPSC-derived neuronal models of Parkinson’s
3. Undertake neuronal differentiation of iPSC lines from Parkinson’s patients and controls into dopamine neurons
4. Contribute ideas for new research projects and develop ideas for generating research income
5. Manage own academic research and administrative activities involving small scale project management
6. Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
7. Collaborate in the preparation of scientific reports and journal articles and present papers and posters
8. Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Selection criteria:
9. Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
10. Expertise in neuronal/glial cell culture, preferably in human pluripotent stem cells
11. Expertise in setting up cellular assays, including image-based experiments
12. Have knowledge of neurodegenerative diseases, such as Parkinson’s
13. Be highly motivated, with the capacity to think creatively and work across teams
14. Show commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
What we offer: Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
15. An excellent contributory pension scheme
16. 38 days annual leave
17. A comprehensive range of childcare services
18. Family leave schemes
19. Cycle and electric car loan schemes
20. Employee Assistance Programme
21. Membership to a variety of social and sports clubs
22. Discounted bus travel and Season Ticket travel loans