Job Details: Scientist - Experimental Immunology | 9 months FTC
Full details of the job.
Vacancy Name
Vacancy No
Vacancy No VN418
Employment Type
Employment Type Fixed Term
Location of role
Location of role Abingdon
About the Company
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.
Key Responsibilities
Key Responsibilities The Experiment Immunology department is actively searching for a Scientist, on a fixed term maternity cover contract, to join one of the target discovery teams at Immunocore. With support from colleagues, you will help generate and implement a suite of in vitro immune cell assays and cancer cell models to aid validation of drug targets and ImmTAC characterisation. You will play a vital role in conducting in vitro pharmacology studies designed to elucidate parameters important for ImmTAC therapeutic efficacy.
The candidate will be an enthusiastic, active learner, keen to take on new challenges and learn new techniques, skills, and areas of biology. The post holder should possess theoretical, practical, and conceptual knowledge in immunology and/or cancer biology, and have demonstrable experience of implementing immunological assays to dissect oncology problems. The candidate will be technically proficient, scientifically creative, capable of independent thought and have a collaborative work ethic. This post provides a fantastic opportunity for both scientific and personal development.
Key Responsibilities:
• Collaborate with colleagues to help build knowledge around drug targets and validation of ImmTAC of strategic interest to Immunocore
• Contribute, with support from colleagues, to generating in vitro models to allow functional validation of ImmTAC specificity.
• Contribute to pharmacological studies focused upon ImmTAC efficacy / mechanism of action
• Participate and present results at internal meetings
• Keep up to date with scientific literature and the latest developments in applicable fields
• Contribute to peer reviewed publications and patents
Experience & knowledge
Essential
• Well-versed in fundamentals of immunology and cancer cell biology
• Experience in testing the effects of therapeutic molecules via immunoassay techniques (e.g. ELISpot, ELISA, flow cytometry)
• Proficient in cell culture and utilising in vitro models to dissect biology and test hypotheses
• Experience with blood processing and isolation of primary human immune cells
• Some Experience with generating genetically modified in vitro model systems (e.g. CRISPR, lentiviral transduction, si/shRNA) and applying these to address hypotheses
• Excellent written and oral communication skills
Desirable
• Experience working with T cells, especially γδ T cells or other unconventional T cell types
• Experienced with the design of multi-colour antibody panels for flow cytometry
• Experience in Fluorescence-activated cell sorting (FACS)
• Proficient in lentiviral transduction
• Pharma or biotech laboratory experience
• Some experience in molecular biology and biochemistry
Education & qualifications
PhD or equivalent in Immunology, Molecular Cell Biology, Oncology, Pharmacology, Biochemistry, or related discipline.
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