200 staff. Limitless Potential. One team. Cancer Research Horizons.
Senior Scientist (Protein Sciences - Small Molecule)
Salary: £41,700 - £51,300 plus benefits
Department: Therapeutic Innovation, R&I
Reports to: Principal Scientist
Location: CRUK Scotland Institute, Glasgow with Low flex (Lab Based)
Contract type/hours: Permanent Contract, Full time 35 hours per week
Closing date: Friday 1st May 2026 23:55pm
Interview Date: Approximately week commencing 11th May
Interview process: Competency based interview with task/presentation
About the role: We have an exciting opportunity for a Senior Scientist in Protein Sciences to join Cancer Research Horizons in our Glasgow lab. You'll lead the expression, purification and QC of protein antigens and related molecules (small molecule drug discovery focus), all of which play a critical role in driving our screening and crystallography programmes.
Working primarily across bacterial and insect systems, you'll deliver high quality, well characterised proteins using a range of biochemical and biophysical methods. You'll collaborate closely with multidisciplinary drug discovery teams, communicate insights clearly, drive strategic decisions, innovate across the existing pipeline, bring strong scientific leadership to the team, and help ensure a safe, efficient lab environment. You'll maintain high‑quality electronic records and help ensure a safe, efficient lab environment.
We're looking for candidates with a PhD (or equivalent experience) in Molecular/Protein Sciences, Chemistry with substantial drug discovery experience, with strong protein production and molecular biology expertise. This is a high impact role that advances our discoveries. If you're adaptable, driven, and ready to make a scientific impact, this is your chance to contribute.
What will you be doing?
* Expression and purification of recombinant proteins using bacterial and insect systems to support screening and crystallography programmes.
* Ensure all production is sufficiently characterised and QC'd using appropriate biochemical and biophysical methods.
* Interpret, analyse and clearly summarise data for presentation to varied audiences.
* Work collaboratively within multi‑disciplinary research teams.
* Communicate effectively, demonstrating openness and respect for others' perspectives.
* Prioritise workload according to project objectives and take responsibility for timely delivery.
* Drive scientific and technical innovation, including through internal and external collaborations, while staying current with developments in the field.
* Maintain accurate and up‑to‑date electronic laboratory notebook records.
* Take responsibility for assigned laboratory equipment and associated duties.
* Uphold safe, compliant and effective working practices.
What are we looking for?
* PhD or equivalent in Molecular Sciences, Protein Sciences, Chemistry or significant experience within a drug discovery environment.
* Significant experience in providing protein production & molecular biology expertise to enable drug discovery projects.
* Ability to work in a fast‑paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals with a can‑do attitude.
* Use of current molecular biology techniques (PCR, cloning) to construct expression vectors and isolate genes.
* Purification of tagged and native proteins via manual, AKTA and automated purification platforms using a range of chromatographic techniques.
* Protein analytical techniques – e.g. protein quantitation assays, SDS‑PAGE analysis, HPLC, Western Blotting and protein modifications e.g. biotinylation.
* Track record of delivering results across a diverse project portfolio by leading and driving strategic and scientific initiatives.
What will I gain?
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high‑quality tools. Our policies and processes enable you to improve your work‑life balance, take positive steps in your career and achieve your personal wellbeing goals.
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