Research Associate in Chemical Biology Job Type: Full-Time.
We are looking for a researcher in chemical biology to contribute to developing an exciting new cyclic peptide discovery approach to make inhibitors of therapeutically relevant, intrinsically disordered proteins during translation. This is an exciting opportunity to be part of an ongoing collaboration between the Walport laboratory and Dr David Balchin's laboratory at the Francis Crick Institute.
This post is to work in the Walport lab based at the Molecular Sciences Research Hub within the Chemistry Department at Imperial College London, whilst collaborating closely with the Balchin Lab based at the Francis Crick Institute. The Walport lab is a highly interdisciplinary lab that uses a wide variety of techniques, spanning from synthetic and peptide chemistry to cell biology, to produce peptide-based chemical tools to study biomedically important proteins. Dr Balchin's laboratory focuses on understanding the mechanisms of protein biogenesis on the ribosome using biochemical reconstitution and structural proteomics.
You will have the opportunity to work between both laboratories and will apply a wide range of techniques in peptide chemistry, protein biochemistry, chemical biology, biophysics and cell biology.
You will join a vibrant research group to develop cyclic peptide inhibitors of a challenging intrinsically disordered drug target. You will carry out novel research employing an mRNA-display-based peptide discovery platform, the RaPID system, to discover tools to modulate the production of this and other proteins during ribosomal translation. We are seeking a motivated and enthusiastic chemical biologist. This project will be multidisciplinary, involving synthetic and peptide chemistry, biophysical characterisation of peptide hits, structural biology and cell biology. We are therefore seeking someone with experience in a selection of these techniques and a willingness to learn others as dictated by the project. Experience with the synthesis, optimisation and testing of peptides is essential and experience with mRNA display screening, general molecular biology approaches and biophysical/biochemical assay would be desirable.
The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).
Access to a range of workplace benefits including a flexible working policy from day 1, generous family leave packages, interest-free season ticket loan schemes for travel and a cycle-to-work scheme
Be part of a diverse, inclusive, and collaborative work culture with various staff networks and resources designed to support your personal and professional wellbeing
This is a full time, fixed term post until 30 September 2027. The expected start date is 01 October 2025 or as soon as possible after this.
To apply for the position, please complete the online application form.
Candidates who have not yet been officially awarded their PhD will initially be appointed as Research Assistant.
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