At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Come join the rapidly expanding Lilly Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome therapy reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene therapy to patients around the world.
Job Responsibilities :
Lilly Gene Therapy Discovery and Platform Research (GTDPR) team is seeking a highly motivated Computational Biologist specializing in next-generation sequencing (NGS) data analysis and/or structural modeling to join our gene therapy platform team. This role will focus on analyzing complex genomic datasets to support AAV vector development, capsid engineering, payload engineering and biodistribution studies. The successful candidate will work collaboratively with cross-functional teams including molecular biology, vector engineering, and pre-clinical development to advance innovative gene therapies from discovery through IND-enabling studies.
This position will be reporting to Executive Director - Vector Engineering and Delivery to evaluate top performing AAV vectors that is fit-for-purpose on select CNS indications.
* Design, execute, and maintain robust bioinformatics pipelines for analyzing bulk and single-cell RNA sequencing, AAV integration analysis, vector genome sequencing, and capsid library screening data.
* Perform end-to-end NGS data analysis including quality control, variant calling, differential expression analysis, and biological interpretation
* Develop computational methods for AAV vector characterization, including integration site analysis, biodistribution assessment, and disease- / tissue-specific biological interpretation.
* Support AAV capsid engineering efforts through computational analysis of structure-function relationships and receptor binding prediction
* Analyze transcriptomic and proteomic datasets to identify therapeutic targets and biomarkers for gene therapy applications
* Communicate and present experimental findings to internal teams and Lilly stakeholders.
* Demonstrate cross-functional collaboration within Lilly Gene Therapy and broader Lilly Research Laboratories (including lab-based scientists), ensuring project milestones are met while maintaining adaptability to evolving research priorities.
Basic Requirements :
* PhD degree in Bioinformatics, Computational Biology, Genomics, or related scientific fields.
* Minimum 2 years industry experience in bioinformatics with focus on NGS data analysis and/or structural modeling.
Additional Preferences :
* Demonstrated publication record in computational biology or bioinformatics methods development.
* Familiarity with AAV biology, capsid engineering, and gene therapy applications
* Excellent written and verbal communication skills with ability to present complex data to diverse audiences
* Strong project management skills with ability to handle multiple concurrent projects
* Experience working in multidisciplinary teams and collaborative research environments
* Attention to detail and commitment to reproducible research practices
* Background in structural biology and protein engineering
* Experience with machine learning applications in biotechnology and drug discovery
Additional Information:
* This role may require up to 10-15% travel for conferences or training.
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Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$156,750 - $250,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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