Job Purpose
We are seeking a dedicated Mass Spectrometry Proteomics Scientist to provide specialist scientific leadership in our proteomics platform development and validation projects. The position is in Prof. Patrick Gunning's group and the successful candidate will work with research colleagues to enable research outcomes, particularly leading the development of innovative proteomic workflows utilizing MS systems and advanced acquisition techniques, including DIA and PRM. This role emphasizes robust maintenance and troubleshooting of mass spectrometry instruments, ensuring seamless operation, and maximizing data integrity for proteomics experiments.
Main Duties and Responsibilities
1. Collaborate with research colleagues, acting as a scientific partner, to design and execute robust proteomics and chemoproteomics experiments, including cell culture, recombinant protein handling, and biochemical components.
2. Take a leading role in the design and execution of proteomics workflows incorporating intact mass analysis (IMA) and peptide mapping analysis (PMA) for protein characterization and quality assessment.
3. Develop and refine workflows using advanced techniques such as DIA and PRM on Thermo Tribrid systems.
4. Integrate automated protocols, including liquid handling systems, to enhance experimental throughput.
5. Using specialist expertise, oversee the routine maintenance and performance optimization of MS instruments.
6. Maintenance and optimization of performance of mass spectrometry instruments.
7. Maintain and operate experimental use of mammalian cell culture systems and preparation of cell-derived material for downstream proteomic and chemoproteomic analyses (i.e. differential protein expression).
8. Diagnose and resolve complex technical issues, ensuring minimal equipment downtime and consistent data quality.
9. Analysis and interpretation of complex proteomic datasets using software tools such as Skyline, FragPipe, or Proteome Discoverer.
10. Compile, interpret, and present data findings to guide the biomarker development strategy and support decision-making.
11. Working as part of the interdisciplinary teams - biologists, chemists, and data scientists - to translate experimental results into actionable insights.
12. Contribution to the preparation of high-quality technical reports, publications, patents and presentations highlighting research outcomes.
Knowledge, Qualifications, Skills and Experience
Essential Knowledge/Qualifications
A1 Ability to demonstrate the competencies required to undertake the duties associated with this level of post having acquired the necessary knowledge and skills in a similar role. OR: Scottish Credit and Qualifications Framework level 12 (PhD) in Analytical Chemistry, Biochemistry, Molecular Biology, or a related field with a focus on proteomics. or equivalent, (including professional accreditation with relevant formal training), and experience of personal development in a similar role.
Essential Skills
* C1 Proficient in advanced acquisition techniques (DIA and PRM).
* C2 Familiarity with data analysis platforms such as Skyline, FragPipe, and Proteome Discoverer.
* C3 Excellent problem-solving abilities and keen attention to detail.
* C4 Strong communication skills with a proven ability to work in collaborative, interdisciplinary teams.
* C5 Ability to manage multiple projects concurrently and meet deadlines in a dynamic research environment.
Desirable Skills
* D1 Strong coding skills to build, validate and deploy reproducible pipelines for statistical analysis, data quality control and automated reporting.
Essential Experience
* E1 Demonstrated hands‑on experience with Orbitrap mass spectrometry systems.
* E2 Proven expertise in the maintenance, troubleshooting, and overall management of MS instrumentation.
* E3 Experience with laboratory automation and liquid handling systems.
* E4 Hands‑on experience in cell culture methods and preparation of material derived from it for proteomics applications (i.e. differential protein expression).
* E5 Hands‑on experience in intact mass analysis (IMA) and peptide mapping analysis (PMA) for protein characterization is preferred.
* E6 Exemplified experience in chemoproteomic methodologies.
Desirable Experience
* F1 Experience in running activity‑based protein profiling experiments.
* F2 Expertise profiling complex matrices through LC‑MS/MS analysis.
* F3 Hands‑on experience designing, executing and interpreting isobaric‑tag workflows.
* F4 Experience with laboratory automation and liquid handling systems.
* F5 Prior experience in development and refinement of workflows using advanced techniques such as DIA and PRM on Thermo Tribrid systems.
* F6 Strong coding skills to build, validate and deploy reproducible pipelines for statistical analysis, data quality control and automated reporting.
* F7 Evidence of leading role in guiding the biomarker development strategy and support decision‑making.
Terms and Conditions
Salary will be Grade 7, £41,064 - £46,049 per annum.
This post is full time and open ended with funding available up until 31st July 2027.
The University of Glasgow has a responsibility to ensure that all employees are eligible to live and work in the UK. If you require a Skilled Worker visa to work in the UK, you will be required to meet the eligibility requirements of the visa route to be assigned a Certificate of Sponsorship.
Please note that this post may be eligible to be sponsored under the Skilled Worker visa route if tradeable points can be used under the Skilled Worker visa rules. For more information please visit: https://www.gov.uk/skilled-worker-visa.
Closing date: 23:45 on Tuesday 26th May 2026
Benefits
As a valued member of our team, you can expect:
* 1 A warm welcoming and engaging organisational culture, where your talents are developed and nurtured, and success is celebrated and shared.
* 2 An excellent employment package with generous terms and conditions including 41 days of leave for full time staff, pension - pensions handbook https://www.gla.ac.uk/myglasgow/payandpensions/pensions/, benefits and discount packages.
* 3 A flexible approach to working.
* 4 A commitment to support your health and wellbeing, including a free 6-month UofG Sport membership for all new staff joining the University https://www.gla.ac.uk/myglasgow/staff/healthwellbeing/.
* 5 We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under‑represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/.
* 6 We endorse the principles of Athena Swan https://www.gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan/ and hold bronze, silver and gold awards across the University.
* 7 We are investing in our organisation, and we will invest in you too. Please visit our website https://www.gla.ac.uk/explore/jobs/ for more information.
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