Job Description
Scientist - Infectious Diseases - Oxford
Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company dedicated to developing and commercializing transformative medicines addressing unmet patient needs in oncology, infectious diseases, and autoimmune diseases. Our R&D leaders are recognized as some of the most successful drug developers in the biotech industry. We foster an environment that encourages collaboration, innovation, and the pursuit of big questions.
Our focus is on delivering first-in-class biological therapies using our innovative soluble TCR platform. Our ImmTAX molecules are precision-engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical needs, including oncology, infectious diseases, and autoimmune diseases. We value our employees as our greatest asset and are committed to an inclusive workplace where everyone feels valued, respected, and empowered.
We encourage applications from individuals of all backgrounds, regardless of race, gender, age, religion, sexual orientation, or any characteristic protected by law.
The primary purpose of this role is to contribute to cross-functional efforts focused on applying the ImmTAX platform or other modalities to develop novel treatments for chronic infections, including HIV, HBV, and EBV-associated diseases. The team is involved in multiple stages of drug discovery and development, from target discovery to clinical trials. Key preclinical research findings are published in Yang H et al., Mol Ther. 2016; 24(11), Fergusson J et al., Hepatology 2020; 72(5), Wallace Z et al., Mol Ther 2024; 32, 678.
The postholder will plan, design, and execute experiments to support the company's pipeline, processes, and technological capabilities, with guidance from their manager. They will demonstrate technical proficiency, scientific creativity, and independent thought, participating in and presenting results at internal meetings, sharing learnings at external scientific conferences, and establishing productive relationships across departments.
Key Responsibilities:
* With instruction and guidance from manager, plan, design, and execute experiments to meet project goals within defined timeframes.
* Perform experiments addressing key scientific questions using techniques such as NextGen sequencing, DD-PCR, qPCR, cell culture, flow cytometry, ELISpots, ELISAs.
* Work in containment level 3 (CL3) facilities handling human viruses.
* Analyze data, interpret results, and make scientific recommendations.
* Expand scientific/technical knowledge through literature review, conference attendance, and peer mentoring.
* Collaborate effectively within matrixed and cross-functional teams.
* Present findings at internal meetings and establish external collaborations.
Qualifications:
* PhD in molecular biology, cell biology, genomics, virology, immunology, or related field with 0-2 years of experience, or a BSc/MSc with significant relevant work experience.
* Experience in bench-based laboratory techniques including molecular methods (Droplet Digital PCR, NextGen sequencing, Genomics/Transcriptomics, PCR, Mutagenesis, qPCR), cell culture.
* Proficiency in working with primary cells and cell lines.
Preferred Qualifications:
* Knowledge or expertise in Immunology, HIV, HBV, EBV.
* Experience with flow cytometry, ELISAs, ELISpots, viral integration site analysis.
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