Job title: Principal Scientist / Engineer
Reporting to: TBC
Department: Process Development
No of Direct reports:0
Location:Bristol
Overview
eXmoor Pharma is the only integrated cell and gene therapy CDMO with over 20 years of consultancy expertise embedded across every stage of the CMC journey - from early-phase strategy to process development, GMP manufacturing and commercialisation. We provide comprehensive support across Viral Vectors, Autologous and Allogeneic Cell Therapies, and RNA technologies. This integrated model enables seamless progression from early-phase strategy through to commercial readiness.
We are looking for a Principal Bioprocess Scientist or Engineer to work in our RNA process development team. The successful candidate will be leading the process development of our clients and partners new and novel therapies. We are looking for a study lead experienced in leading on projects of all sizes including simultaneous and complex projects.
This is an exciting opportunity to work with eXmoor's globally recognised team of scientists, consultants, and engineers, on a wide range of client projects in a rapidly growing market.
Job purpose
The RNA team at eXmoor is growing rapidly as the sector develops and new and novel mRNA-based modalities make their way to the clinic.
As a Principal Scientist in RNA, you will be working closely with all of eXmoor's clients and partners to develop robust, closed, and scalable GMP-compliant manufacturing processes. eXmoor's vision is to build a truly end-to-end service for our partners; therefore, a keen interest and significant expertise, in some or ideally all of the typical unit operations used in mRNA manufacturing will be required. This includes IVT development and optimization, circularization, UFDF, Chromatography, precipitation, LNP encapsulation, and fill-finish.
Responsibilities
* You will conduct your duties to the highest quality standard and in a safe way, complying with all policies and procedures, and with due care and attention for yourself and your peers.
* You will and able to coach and mentor junior study leads
* You will support project management in the successful delivery of client projects
* You will support project management with any scope changes when necessary
* You will use your experience and draw from, as well as contribute to, both literature and scientific knowledge to refine study objectives and protocols.
* You will play an active role in development of eXmoors technical strategy
* You will contribute to the success of the wider business by supporting the GMP, TRN and Capital project teams on a range of client and internal projects
* You will support the development of eXmoors portfolio of projects and work with the business development team as a technical expert in the field
* You will contribute to early technical discussions with prospective clients
* You will demonstrate a forward-looking view on technology development in and around area of expertise to support and develop eXmoors business objectives
* You will comply with lab documentation including Risk assessments, SOPs, COSHH forms, lab notebooks and records
* You will represent eXmoor pharma externally to the broader community.
Qualifications
Essential Qualifications & Experience:
* PhD with 6 years industry experience or equivalent experience.
* BSc/MSc with 10 years of industry experience or equivalent experience.
* Established subject matter expert in the process development of mRNA manufacturing processes.
* Experience with DoE and statistical analysis.
* Proficiency with maths and computing, including MS Office and statistics, DoE, and graphing software
Desirable Qualifications & Experience:
* Expertise in the downstream development of other ATMPs such as viral vectors, VLPs, pDNA or therapeutic proteins
* Knowledge of plasmid design and/or conjugation techniques
* Experience developing or running typical analytical measurements used for analysis of mRNA-based therapies such as IP-RP-HPLC, NTA, CE, Flow cytometry, qPCR, ELISA, gel electrophoresis, and a range of plate-based assays
* Working knowledge of GMP and how to tech transfer new and novel processes into manufacturing
Competences
* Organisation, planning and time management
* Oral and written communication skills
* Leadership and teamworking
* Innovation, inquisitiveness and willingness to learn
* Attention to detail and getting things finished
* Problem solving
* Building constructive relationships and earning respect
* Motivated by growing a bio-technology business in the CGT / biopharmaceutical market