Job description
Site Name: USA - Massachusetts - Waltham, UK - Hertfordshire - Stevenage, UK London New Oxford Street, USA - Massachusetts - Cambridge
Posted Date: Apr 27 2026
POSTING END DATE: Friday, May 1, 2026 / 5P EDT
Business Introduction: At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R & D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
The Executive Medical Director – Translational Medicine Group Leader (TMGL) Aging will lead efforts to bridge preclinical research and clinical development, ensuring the successful transition of innovative therapeutics from the laboratory to Proof of Mechanism/Clinical Activity in the clinic.
The TMGL will provide scientific leadership, strategic direction, and operational oversight for the disease area initiatives to understand mechanism of disease and clinical development strategy.
This role demands expertise in disease pathobiology, translational medicine, early clinical drug development, and biomarker strategies, with a focus on driving innovation across the therapeutic area.
Note: This hybrid position requires working on a GSK site a minimum of two days per week.
Summary of Key Accountabilities / Responsibilities
Scientific Leadership
* Provide disease-level leadership, to develop causal maps of relevant pathobiology (through identifying, accessing or generating translational datasets), and the tools/instruments (endpoints, biomarkers) that enable timely experimentation and prosecution to derisk mechanisms and programmes.
* Strategic leadership for the design, execution, and management to clinical development plans and clinical trials for programmes in the Early Pipeline Unit.
* Provide translational and clinical leadership in defining and executing innovative early development strategies. Provide strategic leadership ensuring that the clinical study designs are aligned with the IEP and CDP, and take into account the scientific rationale, regulatory requirements, product development plan and commercial goals.
Disease area Leadership
* Ensure alignment of scientific and clinical strategies with business objectives through matrix leadership of large cross‑functional teams.
* Drive the evaluation of therapeutic potential and clinical tractability of targets within the disease area.
* Identify transformational opportunities where projects can offer significant benefits to patients.
Program Delivery
* Ensure quality, on‑time, and on‑budget delivery of studies and programs within a therapeutic area of EPU.
* Design and implement experimental medicine studies.
* Oversee risk assessment across programmes and ensure implementation of mitigation strategies.
Line management, Collaboration and Matrix Working
* Manage, mentor and coach early Clinical Development Leads to foster a culture of empowerment, innovation and excellence.
* Collaborate with cross‑functional teams with program counterparts in Advance Pipeline Unit, Commercial, Research Tech and Development organisations.
* Build and maintain networks across internal and external stakeholders, including academic institutions, CROs, and regulators.
* Represent GSK effectively in external collaborations and negotiations.
Problem Solving and Decision Making
* Anticipate challenges and proactively develop strategies to mitigate risks.
* Make decisions balancing risk/benefit with clear understanding of project impact.
* Lead the writing and review of study‑related documents and regulatory submissions.
* Communicate confidently and effectively at all levels, internally and externally.
Ways of Working
* Champion implementation of innovative business processes and strategies to improve clinical development outcomes.
Basic Qualifications
* Academic physician with clinical medical specialty registration, board certification/qualified.
* Industry experience in clinical drug development.
* Experience with planning clinical development for an asset and/or indication.
* Pharmaceutical industry clinical research experience in Aging focused on aging biology; geroscience or age‑related diseases; and potential therapeutic areas.
* Direct line management and leadership experience.
Preferred Qualifications
* Specialist physician with PhD.
* Proven record of creative problem solving in clinical trials and projects (e.g., deriving causal confidence from novel sources, or qualifying a novel endpoint).
* Experience working collaboratively with multiple stakeholders on complex projects.
* Knowledge of translational medicine, clinical research methodology and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and clinical development plans with clear data‑driven decision rules.
* Track record of building and maintaining strong relationships with internal and external stakeholders.
* Strong personal network across relevant scientific and clinical thought leaders, institutions and consortia in relevant therapy area.
* Future‑looking and experimental track record, with demonstrable experience of tech‑enable solutions in biology, translation or clinical development.
Benefits
* If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,625 to $474,375.
* The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role.
* In addition, this position offers an annual bonus and eligibility to participate in our share‑based long‑term incentive program which is dependent on the level of the role.
* Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
EEO Statement
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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